… of 13 C labeling patterns (without formal 13 C flux analysis) … C labeling patterns as 13 C
tracer analysis. Here, we discuss selected important aspects to consider when performing 13 C …

… (C) The factors that favor RET at complex I during reperfusion. The condition to be met for
RET to occur is that 4Dp>2DEh. The rapid oxidation of the succinate that accumulates during …

Targeted therapies and the consequent adoption of “personalized” oncology have achieved
notable successes in some cancers; however, significant problems remain with this …

Macrophages activated by the Gram-negative bacterial product lipopolysaccharide switch
their core metabolism from oxidative phosphorylation to glycolysis 1 . Here we show that …

… 13 C-… C-aspartate infusion significantly increased the 13 C-succinate content of the
ischaemic myocardium compared to normoxia (Fig. 2g). In fact, 13 C-aspartate was the only 13 C-…

Activated macrophages undergo metabolic reprogramming, which drives their pro-inflammatory
phenotype, but the mechanistic basis for this remains obscure. Here, we demonstrate …

The endogenous metabolite itaconate has recently emerged as a regulator of macrophage
function, but its precise mechanism of action remains poorly understood 1 , 2 , 3 . Here we …

… effects on cytochrome c release and mitochondria depolarization (Figures 2C and 2D).
These results indicate that functional OPA1 decreases release of cytochrome c and loss of …

Respiratory chain complexes assemble into functional quaternary structures called
supercomplexes (RCS) within the folds of the inner mitochondrial membrane, or cristae. Here, we …

… that they amplify apoptosis by releasing cytochrome c and other intermembrane space proteins
… , the precise mechanism by which cytochrome c is released remains a matter of intense …