Cohesin: its roles and mechanisms

K Nasmyth, CH Haering - Annual review of genetics, 2009 - annualreviews.org
C terminus of Smc3 but not by fusing its C terminus to the N terminus of Smc1 (43). The
dependency of the interaction on prior binding of the Scc1's C … residues within Scc1's C-terminal …

The structure and function of SMC and kleisin complexes

K Nasmyth, CH Haering - Annu. Rev. Biochem., 2005 - annualreviews.org
… Crucially, an antibody specific to XCAP-C blocked formation of mitotic chromatids in egg …
Antibodies specific to XCAP-C and -E were subsequently used to affinity purify XCAP-C/E …

[PDF][PDF] Towards a unified model of SMC complex function

M Hassler, IA Shaltiel, CH Haering - Current Biology, 2018 - cell.com
… Asymmetric loop extrusion is expected to produce ‘stripes’ in Hi-C contact maps and might
… and members of the Haering lab for many stimulating discussions. Work in the Haering lab is …

Two independent modes of chromatin organization revealed by cohesin removal

…, Y Loe-Mie, NA Fonseca, W Huber, CH Haering… - Nature, 2017 - nature.com
… us to pool the two replicate data sets to generate Hi-C maps for the three different conditions.
We compared Hi-C maps for ΔNipbl and control cells by examining compartments, TADs, …

[PDF][PDF] Molecular architecture of SMC proteins and the yeast cohesin complex

CH Haering, J Löwe, A Hochwagen, K Nasmyth - Molecular cell, 2002 - cell.com
… SMC proteins share a five-domain structure, with a large proteinaceous loop within which
sister chroglobular N- and C-terminal domains separated by a long matids might be entrapped …

[HTML][HTML] Chromosomal cohesin forms a ring

S Gruber, CH Haering, K Nasmyth - Cell, 2003 - cell.com
… We show that N- and C-terminal Scc1 cleavage fragments remain connected due to their
association with different heads of a single Smc1/Smc3 heterodimer. Cleavage of the Smc3 …

Real-time imaging of DNA loop extrusion by condensin

…, S Bisht, E Kim, A Kalichava, CH Haering, C Dekker - Science, 2018 - science.org
It has been hypothesized that SMC protein complexes such as condensin and cohesin
spatially organize chromosomes by extruding DNA into large loops. We directly visualized the …

The cohesin ring concatenates sister DNA molecules

CH Haering, AM Farcas, P Arumugam, J Metson… - Nature, 2008 - nature.com
… a, Fusion of the C terminus of Smc3 with the N terminus of … c, The structure of the yeast Scc1
C terminus bound to the … yeast Smc1 head domain bound to the C-terminal domain of Scc1 …

Degradation of the electrical conductivity in stabilised zirconia system: Part II: Scandia-stabilised zirconia

C Haering, A Roosen, H Schichl, M Schnöller - Solid State Ionics, 2005 - Elsevier
Scandia-stabilised zirconia (ScSZ) electrolyte materials exhibit the highest conductivity of all
the zirconia systems, but the degradation in the ScSZ system has only been investigated yet …

[PDF][PDF] Structure and stability of cohesin's Smc1-kleisin interaction

CH Haering, D Schoffnegger, T Nishino, W Helmhart… - Molecular cell, 2004 - cell.com
… crystal structure of Smc1's ATPase complexed with Scc1's C-terminal domain. The latter forms
a … Interaction of Scc1's N terminus with Smc3 depends on prior C terminus connection with …