[HTML][HTML] SARS-CoV-2 Infects Endothelial Cells In Vivo and In Vitro
…, Z Qin, B Upcin, P Wörsdörfer, CC Midkiff… - Frontiers in cellular …, 2021 - frontiersin.org
SARS-CoV-2 infection can cause fatal inflammatory lung pathology, including thrombosis
and increased pulmonary vascular permeability leading to edema and hemorrhage. In …
and increased pulmonary vascular permeability leading to edema and hemorrhage. In …
[HTML][HTML] Endothelial cell infection and dysfunction, immune activation in severe COVID-19
…, N Iwanaga, J He, R Mi, K Han, CC Midkiff… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: Pulmonary vascular endotheliitis, perivascular inflammation, and immune activation
are observed in COVID-19 patients. While the initial SARS-CoV-2 infection mainly infects …
are observed in COVID-19 patients. While the initial SARS-CoV-2 infection mainly infects …
[HTML][HTML] Acute respiratory distress in aged, SARS-CoV-2–infected African green monkeys but not rhesus macaques
… 25C for 2 minutes, room temperature incubation at 50C for 15 minutes, and an enzyme activation
at 95C … of a denaturing step at 95C for 3 seconds and annealing at 60C for 30 seconds. …
at 95C … of a denaturing step at 95C for 3 seconds and annealing at 60C for 30 seconds. …
Progress on concept inventory assessment tools
The foundation coalition and others have been working on the development of concept
inventory (Cl) assessment instruments patterned after the well-known force concept inventory (…
inventory (Cl) assessment instruments patterned after the well-known force concept inventory (…
[HTML][HTML] Cellular events of acute, resolving or progressive COVID-19 in SARS-CoV-2 infected non-human primates
…, RV Blair, LA Doyle-Meyers, CC Midkiff… - Nature …, 2020 - nature.com
Understanding SARS-CoV-2 associated immune pathology is crucial to develop pan-effective
vaccines and treatments. Here we investigate the immune events from the acute state up …
vaccines and treatments. Here we investigate the immune events from the acute state up …
Reactivation of latent tuberculosis in rhesus macaques by coinfection with simian immunodeficiency virus
…, NA Golden, NK Dutta, CC Midkiff… - Journal of medical …, 2011 - Wiley Online Library
Background Tuberculosis (TB) and AIDS together present a devastating public health challenge.
Over 3 million deaths every year are attributed to these twin epidemics. Annually, ∼11 …
Over 3 million deaths every year are attributed to these twin epidemics. Annually, ∼11 …
[HTML][HTML] TLR7/8 adjuvant overcomes newborn hyporesponsiveness to pneumococcal conjugate vaccine at birth
…, JP Vasilakos, JM Beaurline, MA Tomai, CC Midkiff… - JCI insight, 2017 - ncbi.nlm.nih.gov
Infection is the most common cause of mortality in early life, and immunization is the most
promising biomedical intervention to reduce this burden. However, newborns fail to respond …
promising biomedical intervention to reduce this burden. However, newborns fail to respond …
Lung expression of human angiotensin-converting enzyme 2 sensitizes the mouse to SARS-CoV-2 infection
…, KE Russell-Lodrigue, Z Qin, CC Midkiff… - American journal of …, 2021 - atsjournals.org
Preclinical mouse models that recapitulate some characteristics of coronavirus disease (COVID-19)
will facilitate focused study of pathogenesis and virus–host responses. Human …
will facilitate focused study of pathogenesis and virus–host responses. Human …
Comparative analysis of gammaherpesvirus circular RNA repertoires: conserved and unique viral circular RNAs
…, C Midkiff, D Kolson, S Bai, C Roberts… - Journal of …, 2019 - Am Soc Microbiol
Recent studies have identified circular RNAs (circRNAs) expressed from the Epstein-Barr
virus (EBV) and Kaposi’s sarcoma herpesvirus (KSHV) human DNA tumor viruses. To gain …
virus (EBV) and Kaposi’s sarcoma herpesvirus (KSHV) human DNA tumor viruses. To gain …
[HTML][HTML] Clinical and histopathologic features of a feline SARS-CoV-2 infection model are analogous to acute COVID-19 in humans
…, M Tamil Selvan, S Cowan, YF Kao, CC Midkiff… - Viruses, 2021 - mdpi.com
The emergence and ensuing dominance of COVID-19 on the world stage has emphasized
the urgency of efficient animal models for the development of therapeutics for and …
the urgency of efficient animal models for the development of therapeutics for and …