… differences in small intestinal apoptosis between DBA/2 and Balb/c strains following
intraperitoneal administration of the thymidylate synthase inhibitor Tomudex (Pritchard, unpublished …

Gastric adenocarcinoma carries a poor prognosis, in part due to the late stage of diagnosis.
Risk factors include Helicobacter pylori infection, family history of gastric cancer—in …

The stomach is traditionally regarded as a hollow muscular sac that initiates the second
phase of digestion. Yet this simple view ignores the fact that it is the most sophisticated …

Objectives Loss of intestinal barrier function plays an important role in the pathogenesis of
inflammatory bowel disease (IBD). Shedding of intestinal epithelial cells is a potential cause …

The intestinal epithelium is a critical component of the gut barrier. Composed of a single
layer of intestinal epithelial cells (IECs) held together by tight junctions, this delicate structure …

Background Gastric polyps are important as some have malignant potential. If such polyps
are left untreated, gastric cancer may result. The malignant potential depends on the …

Background Nonsteroidal anti‐inflammatory drugs (NSAIDs) are some of the most prescribed
drugs worldwide and have now probably overtaken Helicobacter pylori as the most …

Iron deficiency anaemia (IDA) is a major cause of morbidity and burden of disease worldwide.
It can generally be diagnosed by blood testing and remedied by iron replacement therapy (…

The epithelia from the crypts of the intestine are exquisitely sensitive to metabolic perturbation
and undergo cell death with the classical morphology of apoptosis. Administration of 40 …

Intestinal epithelial cells migrate from the base of the crypt to the villi where they are shed.
However, little is known about the cell shedding process. We have studied the role of …