… Erik Forsberg and … Forsberg, E, et al. Abnormal mast cells in mice deficient in a heparin-synthesizing
enzyme. Nature 1999. … Erik Forsberg et al. …

Histone acetylation is an important regulatory mechanism that controls transcription and
diverse nuclear processes. While great progress has been made in understanding how …

Heparan sulfates (HSs) are N- and O-sulfated polysaccharide components of proteoglycans,
which are important constituents of the cell surface as well as the extracellular matrix. …

Despite accumulating evidence suggesting local self-maintenance of tissue macrophages
in the steady state, the dogma remains that tissue macrophages derive from monocytes. …

Cardiac macrophages are crucial for tissue repair after cardiac injury but are not well
characterized. Here we identify four populations of cardiac macrophages. At steady state, resident …

Although classified as hematopoietic cells, tissue-resident macrophages (MFs) arise from
embryonic precursors that seed the tissues prior to birth to generate a self-renewing population…

Haematopoietic stem cells (HSCs) self-renew for life, thereby making them one of the few
blood cells that truly age 1 , 2 . Paradoxically, although HSCs numerically expand with age, …

Here we describe a procedure for cloning pigs by the use of in vitro culture systems. Four
healthy male piglets from two litters were born following nuclear transfer of cultured somatic …

Heparin is a sulphated polysaccharide, synthesized exclusively by connective-tissue-type
mast cells 1 and stored in the secretory granules in complex with histamine and various mast-…

Hyperacute rejection of porcine organs by old world primate recipients is mediated through
preformed antibodies against galactosyl-α-1,3-galactose (Galα-1,3-Gal) epitopes expressed …