Embryonic stem (ES) cells are unique in that they are pluripotent and have the ability to self-renew.
The molecular mechanisms that underlie these two fundamental properties are …

Pluripotent stem cells can be derived from embryos or induced from adult cells by reprogramming.
They are unique among stem cells in that they can give rise to all cell types of the body…

… Although hydrophobic residues are usually occupying positions a and d, the e and g positions
are usually being charged [2]. Electron microscope analysis showed a 52–55-nm-long rod…

… The overall recovery kinetics of transiently expressed H10-GFP (Figure 2C), H2B-GFP (Figure
2D), and H3-YFP (Figure 2E) in undifferentiated ES cells were significantly faster than in …

The molecular mechanisms underlying pluripotency and lineage specification from embryonic
stem cells (ESCs) are largely unclear. Differentiation pathways may be determined by the …

An increasing body of evidence indicates that transcription and splicing are coupled, and it is
accepted that chromatin organization regulates transcription. Little is known about the cross…

Loss of pluripotency is a gradual event whose initiating factors are largely unknown. Here we
report the earliest metabolic changes induced during the first hours of differentiation. High-…

… e, Chd1 RNAi cells still express markers of undifferentiated ES cells, such as alkaline
phosphatase (AP; shown in bright field; original magnification, ×100), and SSEA1 and Oct4 (shown …

Introduction Testing for active SARS-CoV-2 infection is a fundamental tool in the public health
measures taken to control the COVID-19 pandemic. Because of the overwhelming use of …

Ancient DNA sequencing has recently provided high-coverage archaic human genomes.
However, the evolution of epigenetic regulation along the human lineage remains largely …