Genomic data allow the large-scale manual or semi-automated assembly of metabolic
network reconstructions, which provide highly curated organism-specific knowledge bases. …

Multiple models of human metabolism have been reconstructed, but each represents only a
subset of our knowledge. Here we describe Recon 2, a community-driven, consensus '…

… was selected as optimal for increasing the production in E. coli. Experimental validation of
the … [5] used a genome-scale model for E. coli and identified and experimentally confirmed …

Systems Biology has a mission that puts it at odds with traditional paradigms of physics and
molecular biology, such as the simplicity requested by Occam’s razor and minimum energy/…

Background An effective, affordable, multivalent meningococcal conjugate vaccine is
needed to prevent epidemic meningitis in the African meningitis belt. Data on the safety and …

… where δ is our perturbation; e j denotes the j th standard basis vector and the notation N r, j
is used to denote the j th column of N r . The new steady state resulting from this perturbation …

We present an experimental and computational pipeline for the generation of kinetic models
of metabolism, and demonstrate its application to glycolysis in Saccharomyces cerevisiae. …

Background To date, several genome-scale network reconstructions have been used to
describe the metabolism of the yeast Saccharomyces cerevisiae, each differing in scope and …

Living organisms persist by virtue of complex interactions among many components organized
into dynamic, environment-responsive networks that span multiple scales and dimensions…

Two divergent modelling methodologies have been adopted to increase our understanding
of metabolism and its regulation. Constraint‐based modelling highlights the optimal path …