Diffuse midline glioma (DMG), including those of the brainstem (diffuse intrinsic pontine glioma),
are pediatric tumors of the central nervous system (CNS). Recognized as the most lethal …

The identification of recurrent driver mutations in genes encoding tyrosine kinases has
resulted in the development of molecularly-targeted treatment strategies designed to improve …

The Zero Childhood Cancer Program is a precision medicine program to benefit children
with poor-outcome, rare, relapsed or refractory cancer. Using tumor and germline whole …

… Tezcan G, Kupesiz A, Ozturk F, et al: Episodes of fever and neutropenia in children with
cancer in a tertiary care medical center in Turkey. Pediatr Hematol Oncol 23:217-229, 2006 33 …

Diffuse intrinsic pontine glioma (DIPG) is an untreatable, heterogeneous high‐grade glioma
(HGG) of the brainstem. This highly aggressive cancer affects mostly young children and is …

This paper describes a formal model for the recognition of on-line handwritten mathematical
expressions using 2D stochastic context-free grammars and hidden Markov models. Hidden …

A collection of 26 wheat genotypes widely grown in Spain during the 20th century was
evaluated in eight contrasting environments in order to quantify breeding achievements in yield …

Medulloblastoma is curable in approximately 70 % of patients. Over the past decade,
progress in improving survival using conventional therapies has stalled, resulting in reduced …

Root system architecture is crucial for wheat adaptation to drought stress, but phenotyping
for root traits in breeding programmes is difficult and time-consuming owing to the …

PI3K/Akt signaling promotes metabolic adaptation to ONC201-mediated disruption of
mitochondrial energy homeostasis in diffuse intrinsic pontine glioma, highlighting the utility of a …