Developments in obesity genetics in the era of genome-wide association studies
Obesity is an important factor contributing to the global burden of morbidity and mortality. By
identifying obesity susceptibility genes, scientists aim to elucidate some of its aetiology. …
identifying obesity susceptibility genes, scientists aim to elucidate some of its aetiology. …
Genetic studies of body mass index yield new insights for obesity biology
…, B Kahali, SI Berndt, AE Justice, TH Pers, FR Day… - Nature, 2015 - nature.com
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of
obesity better, here we conduct a genome-wide association study and Metabochip meta-…
obesity better, here we conduct a genome-wide association study and Metabochip meta-…
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
Here we conducted a large-scale genetic association analysis of educational attainment in
a sample of approximately 1.1 million individuals and identify 1,271 independent genome-…
a sample of approximately 1.1 million individuals and identify 1,271 independent genome-…
An atlas of genetic correlations across human diseases and traits
… arbitrary biased sampling scheme by specifying the selection probabilities as f(C i ): = P[s i =
… that our sample is selected following biased sampling scheme f. Let a ij denote the additive …
… that our sample is selected following biased sampling scheme f. Let a ij denote the additive …
Defining the role of common variation in the genomic and biological architecture of adult human height
…, ML Buchkovich, DC Croteau-Chonka, FR Day… - Nature …, 2014 - nature.com
Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide
significance that together explained one-fifth of the heritability for adult height. By testing …
significance that together explained one-fifth of the heritability for adult height. By testing …
New genetic loci link adipose and insulin biology to body fat distribution
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic
outcomes, independent of overall adiposity. To increase our understanding of the genetic …
outcomes, independent of overall adiposity. To increase our understanding of the genetic …
Partitioning heritability by functional annotation using genome-wide association summary statistics
Recent work has demonstrated that some functional categories of the genome contribute
disproportionately to the heritability of complex diseases. Here we analyze a broad set of …
disproportionately to the heritability of complex diseases. Here we analyze a broad set of …
[HTML][HTML] Circulating tumor DNA analysis guiding adjuvant therapy in stage II colon cancer
Background The role of adjuvant chemotherapy in stage II colon cancer continues to be
debated. The presence of circulating tumor DNA (ctDNA) after surgery predicts very poor …
debated. The presence of circulating tumor DNA (ctDNA) after surgery predicts very poor …
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
Approaches exploiting trait distribution extremes may be used to identify loci associated
with common traits, but it is unknown whether these loci are generalizable to the broader …
with common traits, but it is unknown whether these loci are generalizable to the broader …
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche
Age at menarche is a marker of timing of puberty in females. It varies widely between
individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, …
individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, …