Estrogens are known modulators of monocyte/macrophage functions; however, the
underlying mechanism has not been clearly defined. Recently, a number of estrogen receptor …

The functional significance of cannabinoids in ocular physiology and disease has been
reported some decades ago. In the early 1970s, subjects who smoked Cannabis sativa …

Background & aims TGFβ superfamily member Activin-A is a multifunctional hormone/cytokine
expressed in multiple tissues and cells, where it regulates cellular differentiation, …

Accumulating evidence during the last decades revealed that androgen can exert membrane
initiated actions that involve signaling via specific kinases and the modulation of significant …

Recent advances in cancer immunology revealed immune-related properties of cancer cells
as novel promising therapeutic targets. The two TNF superfamily members, APRIL (…

Inflammation is important for the initiation and progression of breast cancer. We have previously
reported that in monocytes, estrogen regulates TLR4/NFκB-mediated inflammation via …

Background and aims Somatostatin and its analogs may influence hepatic fibrosis
interfering through several mechanisms. The aim of this study was to investigate the effect of …

In a recent study, we employed an in vivo model of retinal excitotoxicity to investigate the
neuroprotective effect of somatostatinergic agents. Intravitreal administration of somatostatin …

purpose. The aim of the present study was to use an in vivo model of retinal excitotoxicity to
investigate the neuroprotective effect of somatostatin (SRIF)-ergic agents. methods. Adult …

Within the hippocampus, the major somatostatin (SRIF) receptor subtype, the sst2A receptor,
is localized at postsynaptic sites of the principal neurons where it modulates neuronal …