User profiles for G. Baier

Gottfried Baier, PhD

Full Professor at the Medical University of Innsbruck, Austria
Verified email at i-med.ac.at
Cited by 11734

NFAT pulls the strings during CD4+ T helper cell effector functions

N Hermann-Kleiter, G Baier - … Journal of the American Society of …, 2010 - ashpublications.org
The Ca 2+ dependent transcription factor family known as nuclear factor of activated T cells (NFAT)
has been shown to be important in T-cell immune responses. Because NFAT …

Protein kinase Cθ: a new essential superstar on the T-cell stage

A Altman, N Isakov, G Baier - Immunology today, 2000 - cell.com
Recent studies have identified protein kinase Cθ (PKCθ), a member of the Ca 2+ -independent
PKC family, as an essential component of the T-cell synapse that cooperates with …

Protein corona of nanoparticles: distinct proteins regulate the cellular uptake

S Ritz, S Schöttler, N Kotman, G Baier… - …, 2015 - ACS Publications
g of water containing 0.09 g of SSNa and 0.6 g of Lutensol AT-50; (iv) phosphonate functionalized
NPs 6.00 g … were mixed together with 24 g of water containing 0.16 g of 2C12-PET and …

A novel ϵ-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

…, G Baier, CL Masters, K Beyreuther, G Evin - Biochemistry, 2002 - ACS Publications
Proteolytic processing of the transmembrane domain of the amyloid precursor protein (APP)
is a key component of Alzheimer's disease pathogenesis. Using C-terminally tagged APP …

The PKC gene module: molecular biosystematics to resolve its T cell functions

G Baier - Immunological reviews, 2003 - Wiley Online Library
… With the help of my wife Gabriele Baier-Bitterlich, we were the first to demonstrate that
PKC-θ was critical for IL-2 in T cells. PKC-θ has been implicated in the isotype-specific …

The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells

…, A Unger, R Torka, T Gruber, R Hinterleitner, G Baier… - Nature, 2014 - nature.com
Tumour metastasis is the primary cause of mortality in cancer patients and remains the key
challenge for cancer therapy 1 . New therapeutic approaches to block inhibitory pathways of …

[HTML][HTML] Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic …

G Baier, D Telford, L Giampa, KM Coggeshall… - Journal of Biological …, 1993 - Elsevier
Members of the protein kinase C (PKC) family of serine/threonine kinases play a key role in
regulating the differentiation and growth of diverse cell types and, to date, the cloning of …

Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host

…, MW Musch, GC Furtado, SA Lira, G Baier… - Nature, 2018 - nature.com
… Mice selected with no signs of myelopoiesis (<16% CD11b + Gr1 + ) in peripheral blood and
<30 g body weight were injected intraperitoneally with 100 μg TLR1/2 agonist Pam3CSK4 (…

[PDF][PDF] The MAGUK family protein CARD11 is essential for lymphocyte activation

…, B Bauer, F D'Acquisto, S Ghosh, WC Yeh, G Baier… - Immunity, 2003 - cell.com
… Wen-Chen Yeh,2 Gottfried Baier,3 In analogy to neurons, antigen receptor stimulation in T
… of the HY TCR in the thymus of female mice (G), and negative selection of the HY TCR in the …

Protein Kinase C θ Affects Ca2+ Mobilization and NFAT Activation in Primary Mouse T Cells

…, C Lutz, K Maly, M Leitges, G Baier - The Journal of …, 2003 - rupress.org
Protein kinase C (PKC)θ is an established component of the immunological synapse and
has been implicated in the control of AP-1 and NF-κB. To study the physiological function of …