Heterochromatin is a key architectural feature of eukaryotic chromosomes, which endows
particular genomic domains with specific functional properties. The capacity of …

Many members of the fungal kingdom have a distinguishing feature, dimorphism, which is the
ability to switch between two morphological forms: a cellular yeast form and a multicellular …

… We have recently determined that the ability of the Ste5 scaffold to retain a bound activated
kinase is, in fact, important for the maintenance of specificity (MA Schwartz & HD Madhani, …

Boundary elements hinder the spread of heterochromatin, yet these sites do not fully
account for the preservation of adjacent euchromatin. Histone variant H2A.Z (Htz1 in yeast) …

In S. cerevisiae, histone variant H2A.Z is deposited in euchromatin at the flanks of silent
heterochromatin to prevent its ectopic spread. We show that H2A.Z nucleosomes are found at …

The conserved histone variant H2A.Z functions in euchromatin to antagonize the spread of
heterochromatin. The mechanism by which histone H2A is replaced by H2A.Z in the …

The gag-pol protein of Rous sarcoma virus (RSV), the precursor to the enzymes responsible
for reverse transcription and integration, is expressed from two genes that lie in different …

Functional genomic studies in Saccharomyces cerevisiae have contributed enormously to
our understanding of cellular processes. Their full potential, however, has been hampered by …

Prior to the chemical steps of mRNA splicing, the extensive base-pairing interaction between
the U4 and U6 spliceosomal snRNAs is disrupted. Here, we use a mutational analysis in …

In yeast, an overlapping set of mitogen-activated protein kinase (MAPK) signaling components
controls mating, haploid invasion, and pseudohyphal development. Paradoxically, a …