The hydroformylation of internal olefin substrates to give predominantly linear ‘oxo’ alcohols
is catalyzed by ruthenium carbonyl ‘melt’ catalysts, wherein the ruthenium carbonyls are …

Niemann-Pick disease type C1 (NPC disease) is a neurodegenerative multi-lipid lysosomal
storage disease caused by mutations in the NPC1 gene presenting with reduced lysosomal …

… After 4 hr the reaction was terminated by rapidly cooling in an ice-water bath. After venting,
98 ml of a clear, light yellow-green solution with no solids present was recovered. The …

… controlled room at 21C under 15 hr of artificial light daily (beginning at 06:OO hr) with free …
at room temperature for 1 hr followed by incubation at 4C for 18 hr. Separation was carried out …

… (9), at least during our 6-hr run times. Finally, there is the question of Cj versus Ce acid
formation. Although an excess of weakly coordinating acetate ion has no significant effect upon …

… Run conditions: 0.001-0.02 M Ru, 120, 1-6 hr.c C12H25NH2 yield data refer to maximum
dodecylamine yields, based uponnitrododecane charged, for reaction times up to 6 hr. The …

… of 3 hr, the colorless supernatant solution was transferred to a trap and the orange,
insolubleproduct was washed with two 30-ml portions of ammonia and dried in vacuo for 24 hr. The …

… hr.). The solution was filtered hot and cooled, and the white crystalline product filtered off,
washed, and dried as in method (1). Pure crystalline tin(t1) formate was obtained by this …

… After 3 to 6 hr CO uptake is complete, the reaction is terminated by rapid cooling, and the
reactor vented. The crude liquid product (83 ml) is separated from the solid, reprecipiated …

Vicinal glycol esters, such as ethylene glycol acetate esters, are prepared from synthesis
gas via homogeneous ruthenium catalysis. Aliphatic carboxylic acids, eg, glacial acetic acid, …