Paul Aurora (Co-chair), Howard Eigen (Co-chair), Hubertus GM Arets, Stephanie D. Davis,
Marcus H. Jones, Janet Stocks, Robert S. Tepper, Daphna Vilozni Summary

There is poor agreement on definitions of different phenotypes of preschool wheezing disorders.
The present Task Force proposes to use the terms episodic (viral) wheeze to describe …

… Significantly, early experiments clearly demonstrated a critical early developmental
window during which microbial colonization could induce appropriate maturation of the T H 2 …

Atopic disease, including atopic dermatitis (eczema), allergy and asthma, has increased in
frequency in recent decades 1 and now affects ∼20% of the population in the developed …

To study the effect of host genetics on gut microbiome composition, the MiBioGen consortium
curated and analyzed genome-wide genotypes and 16S fecal microbiome data from …

Background Pathological features of the airway in young children with severe recurrent
wheeze suggest an association between bacterial colonization and the initiating events of early …

Asthma exacerbations are among the most frequent causes of hospitalization during
childhood, but the underlying mechanisms are poorly understood. We performed a genome-wide …

Asthma control is improved by combining inhaled corticosteroids with long-acting β 2 -agonists.
However, fluctuating asthma control still occurs. We hypothesized that in patients …

BACKGROUND: Changes in the human microbiome have been suggested as a risk factor
for a number of lifestyle-related disorders, such as atopic diseases, possibly through a …

U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical
companies and six patient organisations with the objective of improving the understanding …