Neurosteroids are steroid hormones synthesised de novo in the brain and peripheral nervous
tissues. In contrast to adrenal steroid hormones that act on intracellular nuclear receptors, …

… (H Waller-Evans, AS Alshehri, and E Lloyd-Evans, unpubl.). Although the cause of this
elevated lysosomal Ca 2+ remains to be elucidated, it may contribute to the abnormally enhanced …

Until recently, the mechanisms that regulate endolysosomal calcium homoeostasis were
poorly understood. The discovery of the molecular target of NAADP (nicotinic acid–adenine …

… tion of the protein to the cell membrane (Figure 2H). The endogenous expression level of
LAT-1 … (G and H) Delayed ap alignment of MS spindle in mutant (H) compared to WT (G). (I–L) …

Background The ongoing pandemic has placed an unprecedented strain on global society,
health care, governments, and mass media. Public dissemination of government policies, …

Adhesion-GPCRs provide essential cell-cell and cell-matrix interactions in development,
and have been implicated in inherited human diseases like Usher Syndrome and bilateral …

Background: Adhesion G protein‐coupled receptors (aGPCR) constitute a structurally and
functionally diverse class of seven‐transmembrane receptor proteins. Although for some of …

Abnormalities in the endosomal-autophagic-lysosomal (EAL) system are an early event in
Alzheimer's disease (AD) pathogenesis. However, the mechanisms underlying these …

Bacillus thuringiensis (Bt) proteins are an environmentally safe and effective alternative to
chemical pesticides and have been used as biopesticides, with great commercial success, for …

Nutritional factors play important roles in the etiology of obesity, type 2 diabetes mellitus and
their complications through genotype x environment interactions. We have characterised …