RUNX1/AML1/CBFA2 is essential for definitive hematopoiesis, and chromosomal
translocations affecting RUNX1 are frequently involved in human leukemias. Consequently, the …

The evolutionarily conserved cohesin complex was originally described for its role in
regulating sister-chromatid cohesion during mitosis and meiosis. Cohesin and its regulatory …

Runx transcription factors determine cell fate in many lineages. Maintaining balanced levels
of Runx proteins is crucial, as deregulated expression leads to cancers and developmental …

The three-dimensional regulation of gene transcription involves loop formation between
enhancer and promoter elements, controlling spatiotemporal gene expression in multicellular …

Contact between sister chromatids from S phase to anaphase depends on cohesin, a large
multi-subunit protein complex. Mutations in sister chromatid cohesion proteins underlie the …

… Horsfield, unpublished data). We observed regulation of different sets of genes than those
found by Muto et al. (2011) at the earlier timepoint of 6 hpf, which is not unexpected due the …

Background Sex hormones play important roles in teleost ovarian and testicular development.
In zebrafish, ovarian differentiation appears to be dictated by an oocyte-derived signal via …

Cohesin, a multi-subunit protein complex involved in chromosome organization, is frequently
mutated or aberrantly expressed in cancer. Multiple functions of cohesin, including cell …

The translational stop signal and polypeptide release factor (RF) complexed with
Escherichia coli ribosomes have been shown to be in close physical contact by site-directed …

At zygotic genome activation (ZGA), changes in chromatin structure are associated with new
transcription immediately following the maternal-to-zygotic transition (MZT). The nuclear …