Immunotherapy fails to cure most cancer patients. Preclinical studies indicate that radiotherapy
synergizes with immunotherapy, promoting radiation-induced antitumor immunity. Most …

Nearly two-thirds of cancer patients are treated with radiation therapy (RT), often with the
intent to achieve complete and permanent tumor regression (local control). RT is the primary …

There is a new recognition that the gut microbiota, which consists of a dynamic community of
intestinal bacteria, viruses, fungi, and archaea, can impact the development and function of …

Breast milk HIV-1 transmission is currently the predominant contributor to pediatric HIV
infections. Yet, only ~10% of breastfeeding infants born to untreated HIV-infected mothers …

Activating and recruiting the immune system is critical for successful cancer treatment. Since
the discovery of immune checkpoint inhibitors, immunotherapy has become the standard of …

… JE Himes reports grants from NIH during the conduct of the study. DG Kirsch reports grants
from XRAD Therapeutics, Bristol-Myers Squibb, Varian Medical Systems, and Eli Lilly during …

Fertilization is one of the least understood fundamental biological processes. How sperm
search for and find an egg remains enigmatic. Sperm attraction to egg-derived chemical cues …

African green monkeys (AGMs) are natural primate hosts of simian immunodeficiency virus (SIV).
Interestingly, features of the envelope-specific antibody responses in SIV-infected …

The initial phases of acute human immunodeficiency virus type 1 (HIV-1) infection may be
critical for development of effective envelope (Env)-specific antibodies capable of impeding …

Purpose Despite aggressive multimodal treatment that typically includes definitive or adjuvant
radiation therapy (RT), locoregional recurrence rates approach 50% for patients with …