User profiles for J. K. Pickrell

Joseph Pickrell

Gencove
Verified email at gencove.com
Cited by 24067

Toward a new history and geography of human genes informed by ancient DNA

JK Pickrell, D Reich - Trends in Genetics, 2014 - cell.com
Genetic information contains a record of the history of our species, and technological advances
have transformed our ability to access this record. Many studies have used genome-wide …

Understanding mechanisms underlying human gene expression variation with RNA sequencing

JK Pickrell, JC Marioni, AA Pai, JF Degner… - Nature, 2010 - nature.com
… Author Contributions JK Pickrell performed most of the data analysis. JCM contributed to
the … JK Pritchard with regular input from MS The paper was written by JK Pickrell, YG and JK

A systematic survey of loss-of-function variants in human protein-coding genes

…, J Morris, K Walter, L Jostins, L Habegger, JK Pickrell… - Science, 2012 - science.org
Genome-sequencing studies indicate that all humans carry many genetic variants predicted
to cause loss of function (LoF) of protein-coding genes, suggesting unexpected redundancy …

[PDF][PDF] The genetics of human adaptation: hard sweeps, soft sweeps, and polygenic adaptation

JK Pritchard, JK Pickrell, G Coop - Current biology, 2010 - cell.com
… the National Institutes of Health RO1 MH084703-01 (JK Pritchard), a National Institutes of
Health training grant to the University of Chicago (JK Pickrell), and the Sloan Foundation (GC). …

Genome-wide association study identifies 74 loci associated with educational attainment

…, V Emilsson, SFW Meddens, S Oskarsson, JK Pickrell… - Nature, 2016 - nature.com
Educational attainment is strongly influenced by social and other environmental factors, but
genetic factors are estimated to account for at least 20% of the variation across individuals 1. …

[HTML][HTML] DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines

JT Bell, AA Pai, JK Pickrell, DJ Gaffney, R Pique-Regi… - Genome biology, 2011 - Springer
Background DNA methylation is an essential epigenetic mechanism involved in gene
regulation and disease, but little is known about the mechanisms underlying inter-individual …

Detection and interpretation of shared genetic influences on 42 human traits

JK Pickrell, T Berisa, JZ Liu, L Ségurel, JY Tung… - Nature …, 2016 - nature.com
We performed a scan for genetic variants associated with multiple phenotypes by comparing
large genome-wide association studies (GWAS) of 42 traits or diseases. We identified 341 …

Signals of recent positive selection in a worldwide sample of human populations

JK Pickrell, G Coop, J Novembre, S Kudaravalli… - Genome …, 2009 - genome.cshlp.org
Genome-wide scans for recent positive selection in humans have yielded insight into the
mechanisms underlying the extensive phenotypic diversity in our species, but have focused on …

DNase I sensitivity QTLs are a major determinant of human expression variation

…, R Pique-Regi, JB Veyrieras, DJ Gaffney, JK Pickrell… - Nature, 2012 - nature.com
… contributions from AAP, JBV, DJG and JKPi. GEC and MS provided technical assistance …
written by JFD, AAP, RPR, YG and JKPr. The project was jointly supervised by YG and JKPr. …

Effect of read-mapping biases on detecting allele-specific expression from RNA-sequencing data

…, JK Pickrell, E Nkadori, Y Gilad, JK Pritchard - …, 2009 - academic.oup.com
Motivation: Next-generation sequencing has become an important tool for genome-wide
quantification of DNA and RNA. However, a major technical hurdle lies in the need to map short …