User profiles for J. K. Pickrell
Joseph PickrellGencove Verified email at gencove.com Cited by 24067 |
Toward a new history and geography of human genes informed by ancient DNA
JK Pickrell, D Reich - Trends in Genetics, 2014 - cell.com
Genetic information contains a record of the history of our species, and technological advances
have transformed our ability to access this record. Many studies have used genome-wide …
have transformed our ability to access this record. Many studies have used genome-wide …
Understanding mechanisms underlying human gene expression variation with RNA sequencing
… Author Contributions JK Pickrell performed most of the data analysis. JCM contributed to
the … JK Pritchard with regular input from MS The paper was written by JK Pickrell, YG and JK …
the … JK Pritchard with regular input from MS The paper was written by JK Pickrell, YG and JK …
A systematic survey of loss-of-function variants in human protein-coding genes
Genome-sequencing studies indicate that all humans carry many genetic variants predicted
to cause loss of function (LoF) of protein-coding genes, suggesting unexpected redundancy …
to cause loss of function (LoF) of protein-coding genes, suggesting unexpected redundancy …
[PDF][PDF] The genetics of human adaptation: hard sweeps, soft sweeps, and polygenic adaptation
… the National Institutes of Health RO1 MH084703-01 (JK Pritchard), a National Institutes of
Health training grant to the University of Chicago (JK Pickrell), and the Sloan Foundation (GC). …
Health training grant to the University of Chicago (JK Pickrell), and the Sloan Foundation (GC). …
Genome-wide association study identifies 74 loci associated with educational attainment
Educational attainment is strongly influenced by social and other environmental factors, but
genetic factors are estimated to account for at least 20% of the variation across individuals 1. …
genetic factors are estimated to account for at least 20% of the variation across individuals 1. …
[HTML][HTML] DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines
Background DNA methylation is an essential epigenetic mechanism involved in gene
regulation and disease, but little is known about the mechanisms underlying inter-individual …
regulation and disease, but little is known about the mechanisms underlying inter-individual …
Detection and interpretation of shared genetic influences on 42 human traits
We performed a scan for genetic variants associated with multiple phenotypes by comparing
large genome-wide association studies (GWAS) of 42 traits or diseases. We identified 341 …
large genome-wide association studies (GWAS) of 42 traits or diseases. We identified 341 …
Signals of recent positive selection in a worldwide sample of human populations
Genome-wide scans for recent positive selection in humans have yielded insight into the
mechanisms underlying the extensive phenotypic diversity in our species, but have focused on …
mechanisms underlying the extensive phenotypic diversity in our species, but have focused on …
DNase I sensitivity QTLs are a major determinant of human expression variation
… contributions from AAP, JBV, DJG and JKPi. GEC and MS provided technical assistance …
written by JFD, AAP, RPR, YG and JKPr. The project was jointly supervised by YG and JKPr. …
written by JFD, AAP, RPR, YG and JKPr. The project was jointly supervised by YG and JKPr. …
Effect of read-mapping biases on detecting allele-specific expression from RNA-sequencing data
Motivation: Next-generation sequencing has become an important tool for genome-wide
quantification of DNA and RNA. However, a major technical hurdle lies in the need to map short …
quantification of DNA and RNA. However, a major technical hurdle lies in the need to map short …