User profiles for J. S. Weissman

Jonathan S. Weissman

UCSF/HHMI
Verified email at ucsf.edu
Cited by 127008

Global analysis of protein expression in yeast

…, A Belle, N Dephoure, EK O'Shea, JS Weissman - Nature, 2003 - nature.com
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Newman and members of the Weissman and O'Shea laboratories for discussions; and N. Barkai …

[HTML][HTML] High-content CRISPR screening

…, RS Shapiro, J Shendure, JS Weissman… - Nature Reviews …, 2022 - nature.com
CRISPR screens are a powerful source of biological discovery, enabling the unbiased
interrogation of gene function in a wide range of applications and species. In pooled CRISPR …

Oxidative protein folding in eukaryotes: mechanisms and consequences

BP Tu, JS Weissman - The Journal of cell biology, 2004 - rupress.org
The endoplasmic reticulum (ER) provides an environment that is highly optimized for oxidative
protein folding. Rather than relying on small molecule oxidants like glutathione, it is now …

Global analysis of protein localization in budding yeast

…, LC Gerke, AS Carroll, RW Howson, JS Weissman… - Nature, 2003 - nature.com
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Emr and members of the O'Shea and Weissman laboratories for critical discussion of the work. …

Mammalian microRNAs predominantly act to decrease target mRNA levels

H Guo, NT Ingolia, JS Weissman, DP Bartel - Nature, 2010 - nature.com
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Ingolia, NT, Ghaemmaghami, S., Newman, JR & Weissman, JS Genome-wide analysis in vivo of …

[HTML][HTML] Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression

…, MH Larson, LA Gilbert, JA Doudna, JS Weissman… - Cell, 2013 - cell.com
Targeted gene regulation on a genome-wide scale is a powerful strategy for interrogating,
perturbing, and engineering cellular systems. Here, we develop a method for controlling gene …

[HTML][HTML] CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes

…, EH Whitehead, JA Doudna, WA Lim, JS Weissman… - Cell, 2013 - cell.com
The genetic interrogation and reprogramming of cells requires methods for robust and
precise targeting of genes for expression or repression. The CRISPR-associated catalytically …

Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling

…, S Ghaemmaghami, JRS Newman, JS Weissman - science, 2009 - science.org
Techniques for systematically monitoring protein translation have lagged far behind
methods for measuring messenger RNA (mRNA) levels. Here, we present a ribosome-profiling …

Global landscape of protein complexes in the yeast Saccharomyces cerevisiae

…, S Kanaya, A Shilatifard, E O'Shea, JS Weissman… - Nature, 2006 - nature.com
Identification of protein–protein interactions often provides insight into protein function, and
many cellular processes are performed by stable protein complexes. We used tandem affinity …

[PDF][PDF] Genome-scale CRISPR-mediated control of gene repression and activation

…, MC Bassik, LS Qi, M Kampmann, JS Weissman - Cell, 2014 - cell.com
While the catalog of mammalian transcripts and their expression levels in different cell types
and disease states is rapidly expanding, our understanding of transcript function lags behind…