User profiles for J. S. Weissman
Jonathan S. WeissmanUCSF/HHMI Verified email at ucsf.edu Cited by 127008 |
Global analysis of protein expression in yeast
…, A Belle, N Dephoure, EK O'Shea, JS Weissman - Nature, 2003 - nature.com
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Newman and members of the Weissman and O'Shea laboratories for discussions; and N. Barkai …
Newman and members of the Weissman and O'Shea laboratories for discussions; and N. Barkai …
[HTML][HTML] High-content CRISPR screening
CRISPR screens are a powerful source of biological discovery, enabling the unbiased
interrogation of gene function in a wide range of applications and species. In pooled CRISPR …
interrogation of gene function in a wide range of applications and species. In pooled CRISPR …
Oxidative protein folding in eukaryotes: mechanisms and consequences
BP Tu, JS Weissman - The Journal of cell biology, 2004 - rupress.org
The endoplasmic reticulum (ER) provides an environment that is highly optimized for oxidative
protein folding. Rather than relying on small molecule oxidants like glutathione, it is now …
protein folding. Rather than relying on small molecule oxidants like glutathione, it is now …
Global analysis of protein localization in budding yeast
…, LC Gerke, AS Carroll, RW Howson, JS Weissman… - Nature, 2003 - nature.com
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Emr and members of the O'Shea and Weissman laboratories for critical discussion of the work. …
Emr and members of the O'Shea and Weissman laboratories for critical discussion of the work. …
Mammalian microRNAs predominantly act to decrease target mRNA levels
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Ingolia, NT, Ghaemmaghami, S., Newman, JR & Weissman, JS Genome-wide analysis in vivo of …
Ingolia, NT, Ghaemmaghami, S., Newman, JR & Weissman, JS Genome-wide analysis in vivo of …
[HTML][HTML] Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression
Targeted gene regulation on a genome-wide scale is a powerful strategy for interrogating,
perturbing, and engineering cellular systems. Here, we develop a method for controlling gene …
perturbing, and engineering cellular systems. Here, we develop a method for controlling gene …
[HTML][HTML] CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes
The genetic interrogation and reprogramming of cells requires methods for robust and
precise targeting of genes for expression or repression. The CRISPR-associated catalytically …
precise targeting of genes for expression or repression. The CRISPR-associated catalytically …
Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling
…, S Ghaemmaghami, JRS Newman, JS Weissman - science, 2009 - science.org
Techniques for systematically monitoring protein translation have lagged far behind
methods for measuring messenger RNA (mRNA) levels. Here, we present a ribosome-profiling …
methods for measuring messenger RNA (mRNA) levels. Here, we present a ribosome-profiling …
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae
Identification of protein–protein interactions often provides insight into protein function, and
many cellular processes are performed by stable protein complexes. We used tandem affinity …
many cellular processes are performed by stable protein complexes. We used tandem affinity …
[PDF][PDF] Genome-scale CRISPR-mediated control of gene repression and activation
While the catalog of mammalian transcripts and their expression levels in different cell types
and disease states is rapidly expanding, our understanding of transcript function lags behind…
and disease states is rapidly expanding, our understanding of transcript function lags behind…