… For example, plasma samples have high levels of transcripts released from the liver and
heart, while saliva has abundant transcripts from salivary glands and the oesophagus (KRVK-J., …

Integrated sequencing strategies have provided a broader understanding of the genomic
landscape and molecular classifications of multiple cancer types and have identified various …

Prostate cancer is a complex, multifactorial disease with genetic and environmental factors
involved in its etiology. The search for genetic determinants involved in the disease has …

The most common human cancers are malignant neoplasms of the skin 1 , 2 . Incidence of
cutaneous melanoma is rising especially steeply, with minimal progress in non-surgical …

Multiple myeloma is an incurable malignancy of plasma cells, and its pathogenesis is poorly
understood. Here we report the massively parallel sequencing of 38 tumour genomes and …

The vast majority of coding variants are rare, and assessment of the contribution of rare
variants to complex traits is hampered by low statistical power and limited functional data. …

The long-term integrity of an articulating joint is dependent upon the nourishment of its cartilage
component and the protection of the cartilage surface from friction-induced wear. Loss-of-…

Activation of NF-κB has been noted in many tumor types, however only rarely has this been
linked to an underlying genetic mutation. An integrated analysis of high-density …

Although AKT1 (v-akt murine thymoma viral oncogene homologue 1) kinase is a central
member of possibly the most frequently activated proliferation and survival pathway in cancer, …

Taq DNA polymerase can catalyze nontemplated addition of a nucleotide (principally adenosine)
to the 3′ end of PCR-amplified products. Recently, we showed that this activity, which …