Modular polyketide synthases (PKS) make novel natural products through a series of
preprogrammed chemical steps catalyzed by an assembly line of multidomain modules. Each …

Background and Purpose— A response-adaptive randomization (RAR) trial design actively
adjusts the ratio of participants assigned to each trial arm, favoring the better performing …

Objectives Point-of-care ultrasound (POCUS) is a valuable diagnostic modality that enables
emergency providers to answer focused clinical questions. POCUS relies on the operator to …

Introduction Acute clinical stroke trials are challenging to communicate to patients and families
considering participation. Response adaptive randomization (RAR) is a technique that …

BACKGROUND AND PURPOSE: The communication of adaptive clinical trials can be more
difficult due to the increased complexity of the design itself, especially in an emergent, time-…

Introduction: Acute stroke trials may be improved by using response-adaptive randomization
(RAR) because it works in favor of the trial population on average. With RAR, the ratio of …

This study is conducted with two important goals in mind. First, we present a descriptive
analysis of compound nouns to demonstrate how, in principle, this creative naming device …

… The relative configurations of the adjacent (1,2) or alternate (1,3) stereocenters in the acyclic
carbon chain of 7 were determined using a combination of 3 J H,H coupling constant and …

Curacin A is a polyketide synthase (PKS)-non-ribosomal peptide synthetase-derived natural
product with potent anticancer properties generated by the marine cyanobacterium Lyngbya …

… These higher B-factors between α3 and β11 FluA DH M1 are also observed in the curacin
H, J, K and gephyronic acid DH domains (Fig. S2D, F, H, J). Overall, B-factor analysis and lack …