RAF PROTEIN serine/threonine (Ser/Thr) kinases are essential for growth and development
in worms, flies, frogs and mammals. Receptors that regulate Raf kinases include members …

RAF kinases entered the limelight when our understanding of the genetic nature of cancer
was much less defined and the seminal importance of proto-oncogenes as components of …

Neopterin, a compound derived from GTP, represents a precursor molecule of biopterin that
is an essential cofactor in neurotransmitter synthesis. We have recently reported that in vivo …

… Work in the laboratory of Jakob Troppmair is supported by funds from the DFG (TR 348 2-1,2-2),
FWF (MCBO ZFW011010-08), Tiroler Krebshilfe and MFF Tirol (Nr. 91). …

… Amann and J. Troppmair designed the study, supervised the experiments, discussed the
results and continuous improvement of measurements using different analytic techniques, and …

Normothermic machine perfusion (NMP) has emerged as an innovative organ preservation
technique. Developing an understanding for the donor organ immune cell composition and …

Background The routinely used microbiological diagnosis of ventilator associated pneumonia
(VAP) is time consuming and often requires invasive methods for collection of human …

Background The aim of this work was to confirm the existence of volatile organic compounds
(VOCs) specifically released or consumed by lung cancer cells. Methods 50 million cells of …

The protein kinase cascade Raf-MAPKK/MEK-MAPK/ERK connects protein tyrosine kinase
receptors in the membrane with control of transcription factor activity in the nucleus. We have …

Reactive oxygen species (ROS) are involved in the regulation of many physiological processes.
However, overproduction of ROS under various cellular stresses results in cell death …