Gene drive systems that enable super-Mendelian inheritance of a transgene have the
potential to modify insect populations over a timeframe of a few years. We describe CRISPR-Cas9 …

In the human malaria vector Anopheles gambiae, the gene doublesex (Agdsx) encodes two
alternatively spliced transcripts, dsx-female (AgdsxF) and dsx-male (AgdsxM), that control …

Only female insects transmit diseases such as malaria, dengue and Zika; therefore, control
methods that bias the sex ratio of insect offspring have long been sought. Genetic elements …

Gene drives have enormous potential for the control of insect populations of medical and
agricultural relevance. By preferentially biasing their own inheritance, gene drives can rapidly …

Genetic control aims to reduce the ability of insect pest populations to cause harm via the
release of modified insects. One strategy is to bias the reproductive sex ratio towards males so …

… ) were modelled using default parameters based on Kyrou et al. and expert judgement (Supp. …
Shown in red are the estimates of female fertility from experimental observation in Kyrou et …

Homing-based gene drives use a germline source of nuclease to copy themselves at specific
target sites in a genome and bias their inheritance. Such gene drives can be designed to …

In its natural habitat, the nematode Caenorhabditis elegans encounters a plethora of other
organisms, including many that are pathogenic [1, 2]. The study of interactions between C. …

CRISPR-based gene drives offer promising means to reduce the burden of pests and vector-borne
diseases. These techniques consist of releasing genetically modified organisms …

… 65 K FSC-A … K (population II), or high mCherry intensity and above 120 K FSC-A (population
III). Cells positive only for mCherry fluorescence and FSC-A values between 40 and 60 K …