The granuloma, which is a compact aggregate of immune cells, is the hallmark structure of
tuberculosis. It is historically regarded as a host-protective structure that 'walls off' the infecting …

… a high density of lymphocytes [(166); L. Ramakrishnan, unpublished results], whereas frog
and fish granulomas do not despite being largely similar otherwise [(20, 163); D. Beery & L. …

Tuberculosis, an ancient disease of mankind, remains one of the major infectious causes of
human death. We examine newly discovered facets of tuberculosis pathogenesis and …

TRAIL (also called Apo2L) belongs to the tumor necrosis factor family, activates rapid
apoptosis in tumor cells, and binds to the death-signaling receptor DR4. Two additional TRAIL …

Granulomas, organized aggregates of immune cells, form in response to persistent stimuli
and are hallmarks of tuberculosis. Tuberculous granulomas have long been considered host-…

Infection of vertebrate hosts with pathogenic Mycobacteria, the agents of tuberculosis,
produces granulomas, highly organized structures containing differentiated macrophages and …

Cloud computing has seen tremendous growth, particularly for commercial web applications.
The on-demand, pay-as-you-go model creates a flexible and cost-effective means to …

Treatment of tuberculosis, a complex granulomatous disease, requires long-term multidrug
therapy to overcome tolerance, an epigenetic drug resistance that is widely attributed to …

… We thank the Sanger Institute core sequencing and informatics groups for support, L. Jones
and F. Tekaia for database support, Jessica L. Porter for technical assistance, Derrick Fouts …

The evolutionary survival of Mycobacterium tuberculosis, the cause of human tuberculosis,
depends on its ability to invade the host, replicate, and transmit infection. At its initial …