Simple coumarins and analogues in medicinal chemistry: occurrence, synthesis and biological activity
…, F Roleira, N Milhazes, L Santana… - Current medicinal …, 2005 - ingentaconnect.com
Coumarins, also known as benzopyrones, are present in remarkable amounts in plants,
although their presence has also been detected in microorganisms and animal sources. The …
although their presence has also been detected in microorganisms and animal sources. The …
Medicinal chemistry and bioinformatics-current trends in drugs discovery with networks topological indices
H Gonzalez-Diaz, S Vilar, L Santana… - Current topics in …, 2007 - ingentaconnect.com
… Where AASAlpk is the AASA at spatial lag l weighted by the property pi; L is the number of
nonzero values in the sum; pki and pkj are the values of property k of amino acids ai and aj in …
nonzero values in the sum; pki and pkj are the values of property k of amino acids ai and aj in …
Furocoumarins in medicinal chemistry. Synthesis, natural occurrence and biological activity
The scope of this review encompasses the importance of furocoumarins and the most important
developments in this field that have been made in recent years, with particular emphasis …
developments in this field that have been made in recent years, with particular emphasis …
Relaxation of arterial smooth muscle by calcium sparks
Local increases in intracellular calcium ion concentration ([Ca 2+ ] i ) resulting from activation
of the ryanodine-sensitive calcium-release channel in the sarcoplasmic reticulum (SR) of …
of the ryanodine-sensitive calcium-release channel in the sarcoplasmic reticulum (SR) of …
Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure
…, HH Valdivia, H Cheng, MR Lederer, LF Santana… - Science, 1997 - science.org
… In healthy heart-muscle cells, electrical excitation leads to contraction because depolarization
of the cardiac sarcolemmal membrane opens L-type Ca 2+ channels (or dihydropyridine …
of the cardiac sarcolemmal membrane opens L-type Ca 2+ channels (or dihydropyridine …
Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging
DF Dai, LF Santana, M Vermulst, DM Tomazela… - Circulation, 2009 - Am Heart Assoc
Background— Age is a major risk for cardiovascular diseases. Although mitochondrial reactive
oxygen species have been proposed as one of the causes of aging, their role in cardiac …
oxygen species have been proposed as one of the causes of aging, their role in cardiac …
Mitochondrial oxidative stress mediates angiotensin II–induced cardiac hypertrophy and Gαq overexpression–induced heart failure
…, GW Dorn, YJ Kang, TA Prolla, LF Santana… - Circulation …, 2011 - Am Heart Assoc
Rationale: Mitochondrial dysfunction has been implicated in several cardiovascular diseases;
however, the roles of mitochondrial oxidative stress and DNA damage in hypertensive …
however, the roles of mitochondrial oxidative stress and DNA damage in hypertensive …
Phosphoinositide 3-kinase binds to TRPV1 and mediates NGF-stimulated TRPV1 trafficking to the plasma membrane
…, CA Ufret-Vincenty, L Hua, LF Santana… - The Journal of general …, 2006 - rupress.org
… Trp (2% agar, 0.67% yeast N2 base, 20 mg/liter l-ade, 20 mg/liter l-arg, 30 mg/liter l-iso,
30 mg/liter l-lys, 20 mg/liter l-met, 50 mg/liter l-phe, 200 mg/liter l-thr, 30 mg/liter l-tyr, 150 mg/liter …
30 mg/liter l-lys, 20 mg/liter l-met, 50 mg/liter l-phe, 200 mg/liter l-thr, 30 mg/liter l-tyr, 150 mg/liter …
Genomic and epidemiological monitoring of yellow fever virus transmission potential
…, DA Santos, ML Ferraz, MG Brito, LF Santana… - Science, 2018 - science.org
The yellow fever virus (YFV) epidemic in Brazil is the largest in decades. The recent discovery
of YFV in Brazilian Aedes species mosquitos highlights a need to monitor the risk of …
of YFV in Brazilian Aedes species mosquitos highlights a need to monitor the risk of …
Mitochondrial targeted antioxidant peptide ameliorates hypertensive cardiomyopathy
…, M Nieves-Cintrón, V Kutyavin, LF Santana… - Journal of the American …, 2011 - jacc.org
… ), cyclosporine (0.5 μmol/l), and/or 5-hydroxydecanoate (100 μmol/l). Cardiomyocytes were
then loaded with MitoSOX (5 μmol/l) and CM-DCFDA (5 μmol/l) to measure mitochondrial …
then loaded with MitoSOX (5 μmol/l) and CM-DCFDA (5 μmol/l) to measure mitochondrial …