User profiles for L. Santana

Luis F Santana

- Verified email at ucdavis.edu - Cited by 13026

Lourdes Santana

- Verified email at usc.es - Cited by 9928

Simple coumarins and analogues in medicinal chemistry: occurrence, synthesis and biological activity

…, F Roleira, N Milhazes, L Santana… - Current medicinal …, 2005 - ingentaconnect.com
Coumarins, also known as benzopyrones, are present in remarkable amounts in plants,
although their presence has also been detected in microorganisms and animal sources. The …

Medicinal chemistry and bioinformatics-current trends in drugs discovery with networks topological indices

H Gonzalez-Diaz, S Vilar, L Santana… - Current topics in …, 2007 - ingentaconnect.com
… Where AASAlpk is the AASA at spatial lag l weighted by the property pi; L is the number of
nonzero values in the sum; pki and pkj are the values of property k of amino acids ai and aj in …

Furocoumarins in medicinal chemistry. Synthesis, natural occurrence and biological activity

L Santana, E Uriarte, F Roleira… - Current medicinal …, 2004 - ingentaconnect.com
The scope of this review encompasses the importance of furocoumarins and the most important
developments in this field that have been made in recent years, with particular emphasis …

Relaxation of arterial smooth muscle by calcium sparks

MT Nelson, H Cheng, M Rubart, LF Santana, AD Bonev… - Science, 1995 - science.org
Local increases in intracellular calcium ion concentration ([Ca 2+ ] i ) resulting from activation
of the ryanodine-sensitive calcium-release channel in the sarcoplasmic reticulum (SR) of …

Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure

…, HH Valdivia, H Cheng, MR Lederer, LF Santana… - Science, 1997 - science.org
… In healthy heart-muscle cells, electrical excitation leads to contraction because depolarization
of the cardiac sarcolemmal membrane opens L-type Ca 2+ channels (or dihydropyridine …

Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging

DF Dai, LF Santana, M Vermulst, DM Tomazela… - Circulation, 2009 - Am Heart Assoc
Background— Age is a major risk for cardiovascular diseases. Although mitochondrial reactive
oxygen species have been proposed as one of the causes of aging, their role in cardiac …

Mitochondrial oxidative stress mediates angiotensin II–induced cardiac hypertrophy and Gαq overexpression–induced heart failure

…, GW Dorn, YJ Kang, TA Prolla, LF Santana… - Circulation …, 2011 - Am Heart Assoc
Rationale: Mitochondrial dysfunction has been implicated in several cardiovascular diseases;
however, the roles of mitochondrial oxidative stress and DNA damage in hypertensive …

Phosphoinositide 3-kinase binds to TRPV1 and mediates NGF-stimulated TRPV1 trafficking to the plasma membrane

…, CA Ufret-Vincenty, L Hua, LF Santana… - The Journal of general …, 2006 - rupress.org
… Trp (2% agar, 0.67% yeast N2 base, 20 mg/liter l-ade, 20 mg/liter l-arg, 30 mg/liter l-iso,
30 mg/liter l-lys, 20 mg/liter l-met, 50 mg/liter l-phe, 200 mg/liter l-thr, 30 mg/liter l-tyr, 150 mg/liter …

Genomic and epidemiological monitoring of yellow fever virus transmission potential

…, DA Santos, ML Ferraz, MG Brito, LF Santana… - Science, 2018 - science.org
The yellow fever virus (YFV) epidemic in Brazil is the largest in decades. The recent discovery
of YFV in Brazilian Aedes species mosquitos highlights a need to monitor the risk of …

Mitochondrial targeted antioxidant peptide ameliorates hypertensive cardiomyopathy

…, M Nieves-Cintrón, V Kutyavin, LF Santana… - Journal of the American …, 2011 - jacc.org
… ), cyclosporine (0.5 μmol/l), and/or 5-hydroxydecanoate (100 μmol/l). Cardiomyocytes were
then loaded with MitoSOX (5 μmol/l) and CM-DCFDA (5 μmol/l) to measure mitochondrial …