Successful phagolysosomal maturation is an important innate immune response to intracellular
infection. However, Mycobacterium tuberculosis (Mtb) can manipulate and inhibit this …

… Mary P O'Sullivan … Jeffrey W Tyner, Osamu Uchida, Naohiro Kajiwara, Edy Y Kim, Mary
P O'Sullivan, Michael J Walter & Michael J Holtzman … Mary P O'Sullivan …

The concept that airway inflammation leads to airway disease has led to a widening search
for the types of cellular and molecular interactions responsible for linking the initial stimulus …

Recent advances in immunometabolism link metabolic changes in stimulated macrophages
to production of IL-1β, a crucial cytokine in the innate immune response to Mycobacterium …

This audit analysed the Tanner and Whitehouse II twenty bone (TW2) method of bone age
assessment which was used in our department, and compared it with the Greulich and Pyle (…

… O’Leary S, O’Sullivan MP, Keane J. IL-10 blocks phagosome maturation in
Mycobacterium tuberculosis-infected human macrophages. Am J Respir Cell Mol Biol 2011;45:172–180. …

Mycobacterium tuberculosis (Mtb) enters the host in aerosol droplets deposited in lung alveoli,
where the bacteria first encounter lung-resident alveolar macrophages. We studied the …

We demonstrate that the conductance of a field-effect transistor (FET) gated by a layer of
nanometer-sized quantum dots is sensitive to the absorption of single photons. Rather than …

… immune system such as macrophages) are specially programmed to live or die based on
these early decision points (JW Tyner, MP O'Sullivan, and MJ Holtzman, unpublished results). …

A zebrafish genetic screen for determinants of susceptibility to Mycobacterium marinum
identified a hypersusceptible mutant deficient in lysosomal cysteine cathepsins that manifests …