Organismal development requires the reproducible unfolding of an ordered sequence of
discrete steps (cell fate determination, migration, tissue folding, etc.) in both time and space. …

Oscillatory and sequential processes have been implicated in the spatial patterning of many
embryonic tissues. For example, molecular clocks delimit segmental boundaries in …

Animals display substantial inter-species variation in the rate of embryonic development
despite a broad conservation of the overall sequence of developmental events. Differences in …

The vertebrate body displays a segmental organization that is most conspicuous in the periodic
organization of the vertebral column and peripheral nerves. This metameric organization …

The segmental organization of the vertebral column is established early in embryogenesis,
when pairs of somites are rhythmically produced by the presomitic mesoderm (PSM). The …

… the establishment of the first mouse presomitic mesoderm explant systems, as well as the
recapitulation of the segmentation clock using both mouse and human PSCs (Diaz-Cuadros et …

Formation of the body of vertebrate embryos proceeds sequentially by posterior addition of
tissues from the tail bud. Cells of the tail bud and the posterior presomitic mesoderm, which …

Tubulins, the building block of microtubules (MTs), play a critical role in both supporting and
regulating neurite growth. Eukaryotic genomes contain multiple tubulin isotypes, and their …

Although Hox genes specify the differentiation of neuronal subtypes along the anterior-posterior
axis, their mode of action is not entirely understood. Using two subtypes of the touch …

Human muscle is a hierarchically organised tissue with its contractile cells called myofibers
packed into large myofiber bundles. Each myofiber contains periodic myofibrils built by …