The RUNX1/AML1 gene is the most frequent target for chromosomal translocation in leukemia.
In addition, recent studies have demonstrated point mutations in the RUNX1 gene as …

T lymphocytes differentiate in discrete stages within the thymus. Immature thymocytes lacking
CD4 and CD8 coreceptors differentiate into double-positive cells (CD4 + CD8 + ), which …

Familial platelet disorder with predisposition to acute myelogenous leukemia (FPD/AML) is
an autosomal dominant familial platelet disorder characterized by thrombocytopenia and a …

Deregulated expression of the MYC transcription factor occurs in most human cancers and
correlates with high proliferation, reprogrammed cellular metabolism and poor prognosis 1 . …

… However, because oipA, cag PAI, babA2, and vacA s and m status were not independent
of one another (as described above), we chose to look at all predictor variables at the same …

The AML1 gene encoding the DNA-binding -subunit in the Runt domain family of
heterodimeric transcription factors has been noted for its frequent involvement in chromosomal …

The transcription factor PU.1 is required for normal blood cell development. PU.1 regulates
the expression of a number of crucial myeloid genes, such as the macrophage colony-…

… M. paratuberculosis), which causes a similar disease in animals, and is present in the human
food chain. Considerable evidence supports the presence of M… response to recombinant M. …

A broad range of human leukemias carries RUNX1 and MLL genetic alterations. Despite
such widespread involvements, the relationship between RUNX1 and MLL has never been …

Background: A reliable challenge model is needed to evaluate Helicobacter pylori vaccine
candidates. Methods: A cag pathogenicity island negative, OipA positive, multiple antibiotic …