User profiles for N. V. Terekhanova

Nadezhda V. Terekhanova

Postdoctoral Research Associate, Washington University School of Medicine in St. Louis
Verified email at wustl.edu
Cited by 1286

[PDF][PDF] Proteogenomic data and resources for pan-cancer analysis

…, Z Shi, D Singhal, X Song, E Storrs, NV Terekhanova… - Cancer cell, 2023 - cell.com
The National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium (CPTAC)
investigates tumors from a proteogenomic perspective, creating rich multi-omics datasets …

[PDF][PDF] Proteogenomic characterization of pancreatic ductal adenocarcinoma

…, Y Dou, W Jiang, Y Liao, Z Shi, NV Terekhanova… - Cell, 2021 - cell.com
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor patient
survival. Toward understanding the underlying molecular alterations that drive PDAC …

[HTML][HTML] Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer

…, R Varghese, JR Mashl, J Ponce, NV Terekhanova… - Nature …, 2022 - nature.com
Pancreatic ductal adenocarcinoma is a lethal disease with limited treatment options and
poor survival. We studied 83 spatial samples from 31 patients (11 treatment-naïve and 20 …

[HTML][HTML] Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidates for targeted treatment

…, FM Rodrigues, NV Terekhanova… - Nature …, 2021 - nature.com
Abstract Development of candidate cancer treatments is a resource-intensive process, with
the research community continuing to investigate options beyond static genomic …

[HTML][HTML] Epigenetic and transcriptomic characterization reveals progression markers and essential pathways in clear cell renal cell carcinoma

Y Wu, NV Terekhanova, W Caravan… - Nature …, 2023 - nature.com
Identifying tumor-cell-specific markers and elucidating their epigenetic regulation and spatial
heterogeneity provides mechanistic insights into cancer etiology. Here, we perform snRNA-…

[HTML][HTML] Fast Evolution from Precast Bricks: Genomics of Young Freshwater Populations of Threespine Stickleback Gasterosteus aculeatus

NV Terekhanova, MD Logacheva, AA Penin… - PLoS …, 2014 - journals.plos.org
Adaptation is driven by natural selection; however, many adaptations are caused by weak
selection acting over large timescales, complicating its study. Therefore, it is rarely possible to …

[PDF][PDF] Pan-cancer proteogenomics connects oncogenic drivers to functional states

…, M Sibai, V Ruiz-Serra, WW Liang, NV Terekhanova… - Cell, 2023 - cell.com
Cancer driver events refer to key genetic aberrations that drive oncogenesis; however, their
exact molecular mechanisms remain insufficiently understood. Here, our multi-omics pan-…

[PDF][PDF] Pan-cancer analysis of post-translational modifications reveals shared patterns of protein regulation

…, S Schürer, ME Selvan, J Tan, NV Terekhanova… - Cell, 2023 - cell.com
Post-translational modifications (PTMs) play key roles in regulating cell signaling and
physiology in both normal and cancer cells. Advances in mass spectrometry enable high-…

[HTML][HTML] Epigenetic regulation during cancer transitions across 11 tumour types

NV Terekhanova, A Karpova, WW Liang… - Nature, 2023 - nature.com
Chromatin accessibility is essential in regulating gene expression and cellular identity, and
alterations in accessibility have been implicated in driving cancer initiation, progression and …

[HTML][HTML] Signaling pathways activation profiles make better markers of cancer than expression of individual genes

NM Borisov, NV Terekhanova, AM Aliper, LS Venkova… - Oncotarget, 2014 - ncbi.nlm.nih.gov
Identification of reliable and accurate molecular markers remains one of the major challenges
of contemporary biomedicine. We developed a new bioinformatic technique termed …