User profiles for N. V. Terekhanova
Nadezhda V. TerekhanovaPostdoctoral Research Associate, Washington University School of Medicine in St. Louis Verified email at wustl.edu Cited by 1286 |
[PDF][PDF] Proteogenomic data and resources for pan-cancer analysis
The National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium (CPTAC)
investigates tumors from a proteogenomic perspective, creating rich multi-omics datasets …
investigates tumors from a proteogenomic perspective, creating rich multi-omics datasets …
[PDF][PDF] Proteogenomic characterization of pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor patient
survival. Toward understanding the underlying molecular alterations that drive PDAC …
survival. Toward understanding the underlying molecular alterations that drive PDAC …
[HTML][HTML] Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer
…, R Varghese, JR Mashl, J Ponce, NV Terekhanova… - Nature …, 2022 - nature.com
Pancreatic ductal adenocarcinoma is a lethal disease with limited treatment options and
poor survival. We studied 83 spatial samples from 31 patients (11 treatment-naïve and 20 …
poor survival. We studied 83 spatial samples from 31 patients (11 treatment-naïve and 20 …
[HTML][HTML] Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidates for targeted treatment
…, FM Rodrigues, NV Terekhanova… - Nature …, 2021 - nature.com
Abstract Development of candidate cancer treatments is a resource-intensive process, with
the research community continuing to investigate options beyond static genomic …
the research community continuing to investigate options beyond static genomic …
[HTML][HTML] Epigenetic and transcriptomic characterization reveals progression markers and essential pathways in clear cell renal cell carcinoma
Identifying tumor-cell-specific markers and elucidating their epigenetic regulation and spatial
heterogeneity provides mechanistic insights into cancer etiology. Here, we perform snRNA-…
heterogeneity provides mechanistic insights into cancer etiology. Here, we perform snRNA-…
[HTML][HTML] Fast Evolution from Precast Bricks: Genomics of Young Freshwater Populations of Threespine Stickleback Gasterosteus aculeatus
Adaptation is driven by natural selection; however, many adaptations are caused by weak
selection acting over large timescales, complicating its study. Therefore, it is rarely possible to …
selection acting over large timescales, complicating its study. Therefore, it is rarely possible to …
[PDF][PDF] Pan-cancer proteogenomics connects oncogenic drivers to functional states
Cancer driver events refer to key genetic aberrations that drive oncogenesis; however, their
exact molecular mechanisms remain insufficiently understood. Here, our multi-omics pan-…
exact molecular mechanisms remain insufficiently understood. Here, our multi-omics pan-…
[PDF][PDF] Pan-cancer analysis of post-translational modifications reveals shared patterns of protein regulation
Post-translational modifications (PTMs) play key roles in regulating cell signaling and
physiology in both normal and cancer cells. Advances in mass spectrometry enable high-…
physiology in both normal and cancer cells. Advances in mass spectrometry enable high-…
[HTML][HTML] Epigenetic regulation during cancer transitions across 11 tumour types
Chromatin accessibility is essential in regulating gene expression and cellular identity, and
alterations in accessibility have been implicated in driving cancer initiation, progression and …
alterations in accessibility have been implicated in driving cancer initiation, progression and …
[HTML][HTML] Signaling pathways activation profiles make better markers of cancer than expression of individual genes
Identification of reliable and accurate molecular markers remains one of the major challenges
of contemporary biomedicine. We developed a new bioinformatic technique termed …
of contemporary biomedicine. We developed a new bioinformatic technique termed …