User profiles for N. Ceglia

Nicholas Ceglia

Memorial Sloan Kettering Cancer Center
Verified email at mskcc.org
Cited by 3032

[HTML][HTML] Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer

…, C Olcese, N Pang, E Patterson, J Lihm, N Ceglia… - Nature, 2023 - nature.com
… cohort (n = 19 patients treated with atezolizumab, n = 16 treated with autogene cevumeran),
and we correlated immune response to RFS in a biomarker-evaluable cohort (n = 16 …

[HTML][HTML] Reprogramming of the circadian clock by nutritional challenge

…, VR Patel, S De Mateo, R Orozco-Solis, NJ Ceglia… - Cell, 2013 - cell.com
Circadian rhythms and cellular metabolism are intimately linked. Here, we reveal that a high-fat
diet (HFD) generates a profound reorganization of specific metabolic pathways, leading …

[HTML][HTML] Ovarian cancer mutational processes drive site-specific immune evasion

…, F Uhlitz, N Ceglia, JLP Lim, M Wu, N Mohibullah… - Nature, 2022 - nature.com
High-grade serous ovarian cancer (HGSOC) is an archetypal cancer of genomic instability 1
, 2 , 3 – 4 patterned by distinct mutational processes 5 , 6 , tumour heterogeneity 7 , 8 – 9 …

[PDF][PDF] Atlas of circadian metabolism reveals system-wide coordination and communication between clocks

KA Dyar, D Lutter, A Artati, NJ Ceglia, Y Liu, D Armenta… - Cell, 2018 - cell.com
Metabolic diseases are often characterized by circadian misalignment in different tissues,
yet how altered coordination and communication among tissue clocks relate to specific …

Probabilistic cell-type assignment of single-cell RNA-seq for tumor microenvironment profiling

…, C O'Flanagan, EA Chavez, JLP Lim, N Ceglia… - Nature …, 2019 - nature.com
… Half of the simulated cells (n = 1,000 training, n = 1,000 … Let Y be a cell-by-gene expression
matrix of raw counts for N cells … categorical indicator vector z = {z n } that encodes to which of …

[PDF][PDF] Tim-4+ cavity-resident macrophages impair anti-tumor CD8+ T cell immunity

…, S Schad, MD Green, MD Hellmann, V Allaj, N Ceglia… - Cancer Cell, 2021 - cell.com
Immune checkpoint blockade (ICB) has been a remarkable clinical advance for cancer; however,
the majority of patients do not respond to ICB therapy. We show that metastatic disease …

[PDF][PDF] Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism

S Masri, P Rigor, M Cervantes, N Ceglia, C Sebastian… - Cell, 2014 - cell.com
… (B and C) ChIP analysis in WT and SIRT1 KO livers at indicated ZTs using n = 3 independent
livers per genotype and time point. Left panels display gene expression profile, and right …

[HTML][HTML] Single-cell genomic variation induced by mutational processes in cancer

…, V Bojilova, RA Moore, N Rusk, F Uhlitz, N Ceglia… - Nature, 2022 - nature.com
How cell-to-cell copy number alterations that underpin genomic instability 1 in human
cancers drive genomic and phenotypic variation, and consequently the evolution of cancer 2 , …

[HTML][HTML] Dissociation of solid tumor tissues with cold active protease for single-cell RNA-seq minimizes conserved collagenase-associated stress responses

…, M Wiens, B Hewitson, J Hopkins, J Pham, N Ceglia… - Genome biology, 2019 - Springer
Background Single-cell RNA sequencing (scRNA-seq) is a powerful tool for studying complex
biological systems, such as tumor heterogeneity and tissue microenvironments. However, …

Clonal fitness inferred from time-series modelling of single-cell cancer genomes

S Salehi, F Kabeer, N Ceglia, M Andronescu… - Nature, 2021 - nature.com
… Supplementary Table 3 lists the resulting N e estimates. Since fitClone is robust to the choice
of N e in this range, we set \({N}_{{\rm{e}}}=500.0\) for all datasets analysed in this paper. …