The p42/p44 mitogen-activated protein kinase (MAPK) cascade includes Ras, Raf, Mek,
and Erk MAPK. To determine the effect of a full knockout at a single level of this signaling …

Using the yeast Cryptococcus neoformans, we describe a mechanism by which
transposons are initially targeted for RNAi-mediated genome defense. We show that intron-containing …

Adaptive thermogenesis has attracted much attention because of its ability to increase
systemic energy expenditure and to counter obesity and diabetes 1 , 2 – 3 . Recent data have …

We characterize the Polycomb system that assembles repressive subtelomeric domains of
H3K27 methylation (H3K27me) in the yeast Cryptococcus neoformans. Purification of this …

Erk1/2 mitogen-activated protein kinases (MAPKs) are often hyperactivated in human cancers,
where they affect multiple processes, including proliferation. However, the effects of Erk1/…

Cytosine methylation of DNA is a widespread modification of DNA that plays numerous
critical roles. In the yeast Cryptococcus neoformans, CG methylation occurs in transposon-rich …

The peroxisome proliferator-activated receptor γ coactivator-1α (Ppargc1a) gene encodes
several PGC-1α isoforms that regulate mitochondrial bioenergetics and cellular adaptive …

Cell transformation is often a result of constitutive activation of genes in signaling pathways
that regulate cell proliferation and differentiation. Indeed, the Ras/Raf/MEK/ERK mitogen-…

… Dumesic et al. identify a repressive upstream open reading frame (uORF) in the PPARGC1A
mRNA. Loss of function of the uORF in mice raises PGC1a function and is protective …

High-resolution nucleosome occupancy maps of heterochromatic regions of wild-type and
silencing-defective mutants of the fission yeast Schizosaccharomyces pombe revealed that …