User profiles for P. Mita
Paolo MitaNYULMC Verified email at nyumc.org Cited by 1928 |
The role of retrotransposable elements in ageing and age-associated diseases
The genomes of virtually all organisms contain repetitive sequences that are generated by
the activity of transposable elements (transposons). Transposons are mobile genetic …
the activity of transposable elements (transposons). Transposons are mobile genetic …
How retrotransposons shape genome regulation
Retrotransposons are mutagenic units able to move within the genome. Despite many defenses
deployed by the host to suppress potentially harmful activities of retrotransposons, these …
deployed by the host to suppress potentially harmful activities of retrotransposons, these …
[HTML][HTML] Affinity proteomics reveals human host factors implicated in discrete stages of LINE-1 retrotransposition
LINE-1s are active human DNA parasites that are agents of genome dynamics in evolution
and disease. These streamlined elements require host factors to complete their life cycles, …
and disease. These streamlined elements require host factors to complete their life cycles, …
SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling
KRAS is the most frequently mutated human oncogene, and KRAS inhibition has been a
longtime goal. Recently, inhibitors were developed that bind KRAS G12C -GDP and react with …
longtime goal. Recently, inhibitors were developed that bind KRAS G12C -GDP and react with …
Retrotransposon insertions in the clonal evolution of pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is typically diagnosed after the disease has
metastasized; it is among the most lethal forms of cancer. We recently described aberrant …
metastasized; it is among the most lethal forms of cancer. We recently described aberrant …
LINE-1 protein localization and functional dynamics during the cell cycle
… To investigate this further, Mita et al. used human cancer cells grown in the lab and tracked
LINE-1 during the different stages of the cell cycle. The results showed that LINE-1 enters the …
LINE-1 during the different stages of the cell cycle. The results showed that LINE-1 enters the …
LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S phase checkpoint
… At P < 0.03, we observed a correlation between ORF1p and ATM-targeted phosphosites
on both proteins: BRCA1-S1545 (S1524 in uniprot) (58) and NBN-S343 (59) (Fig. 5B). LINE-1 …
on both proteins: BRCA1-S1545 (S1524 in uniprot) (58) and NBN-S343 (59) (Fig. 5B). LINE-1 …
Transcription factor profiling reveals molecular choreography and key regulators of human retrotransposon expression
…, M Grivainis, D Kahler, C Yun, P Mita… - Proceedings of the …, 2018 - National Acad Sciences
Transposable elements (TEs) represent a substantial fraction of many eukaryotic genomes,
and transcriptional regulation of these factors is important to determine TE activities in …
and transcriptional regulation of these factors is important to determine TE activities in …
BRCA1 and S phase DNA repair pathways restrict LINE-1 retrotransposition in human cells
… , error = sd, two-tailed distribution homoscedastic t test, *P ≤ 0.05, **P ≤ 0.01) f, Scheme of
the modes of L1 … The P values intervals were reported in the corresponding figure legends. …
the modes of L1 … The P values intervals were reported in the corresponding figure legends. …
Dissection of affinity captured LINE-1 macromolecular complexes
… A cut-off of p=10À3 for RNase-sensitivity is indicated by a light gray circle; proteins that
are RNase-sensitive with a statistical significance of p<10À3 are outside the circle. Proteins …
are RNase-sensitive with a statistical significance of p<10À3 are outside the circle. Proteins …