Background A safe and efficacious vaccine against severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of …

Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …

Background Vitamin D is crucial for maintenance of musculoskeletal health, and might also
have a role in extraskeletal tissues. Determinants of circulating 25-hydroxyvitamin D …

Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide.
To date, identification of common genetic variants influencing blood pressure has proven …

… We also perform a simulation study to estimate a P-value significance threshold for high-…
Prior to a more extensive study, we suggest a more conservative significance threshold of P = …

Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer
and several age-associated diseases. We report here a genome-wide meta-analysis of …

A polygenic score (PGS) or polygenic risk score (PRS) is an estimate of an individual’s
genetic liability to a trait or disease, calculated according to their genotype profile and relevant …

… This research has been conducted using the UK Biobank Resource under application
18177 (Dr O'Reilly). We thank Hei Man Wu for providing critical feedback regarding this …

… diet and 1 plaque-promoting chow group were additionally challenged with exogenous P.
gin- … Exogenous P. gingivalis challenge by gastric gavage did not promote either more severe …

Concentrations of liver enzymes in plasma are widely used as indicators of liver disease.
We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci …