Microsystems create new opportunities for the spatial and temporal control of cell growth
and stimuli by combining surfaces that mimic complex biochemistries and geometries of the …

Physicochemical modelling of signal transduction links fundamental chemical and physical
principles, prior knowledge about regulatory pathways, and experimental data of various …

… for two distinct ligands (A 1 and A 2 ) and their cognate receptors (B 1 and B 2 ) that converge
on a downstream signaling kinase (C) leading to its activation by phosphorylation (C P ). …

… This consistent shift of all six patients is statistically significant (P < 0.05, binomial test), as
are the individual increases in AXL and MITF for four of the six sample pairs (P < 0.05, t test; …

… enriched with one or more of our T cell signatures (p < 1 3 10 … in two signatures of
immunotherapy sensitivity (p < 2.65 3 10 … P, COX regression p value; Pc, COX regression p value …

An understanding of protective immunity to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) is critical for vaccine and public health strategies aimed at ending the global …

In microorganisms, noise in gene expression gives rise to cell-to-cell variability in protein
concentrations 1 , 2 , 3 , 4 , 5 , 6 , 7 . In mammalian cells, protein levels also vary 8 , 9 , 10 and …

… relative distribution of the various species depends on the concentration of HSF, and we
believe that the upper bands represent complexes containing multiple HSF molecules (Sorger …

… P < 0.008 to P < 0.00001, by Fisher exact test) were identified between wild-type and Hct-MAD2
+/- cells (Fig. 4a, b). We did not identify differences for chromosome 17 (data not shown). …

Obesity is a major cancer risk factor, but how differences in systemic metabolism change the
tumor microenvironment (TME) and impact anti-tumor immunity is not understood. Here, we …