User profiles for R. M. Counago
Rafael M. CouñagoCentro de Química Medicinal - UNICAMP Verified email at unicamp.br Cited by 1547 |
[HTML][HTML] Mitochondrial uncoupling protein-dependent signaling in plant bioenergetics and stress response
P Barreto, RM Counago, P Arruda - Mitochondrion, 2020 - Elsevier
The biological function of plant mitochondrial uncoupling proteins (pUCPs) has been a matter
of considerable controversy. For example, the pUCP capacity to uncouple respiration from …
of considerable controversy. For example, the pUCP capacity to uncouple respiration from …
[HTML][HTML] Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae
Cadmium is a transition metal ion that is highly toxic in biological systems. Although relatively
rare in the Earth’s crust, anthropogenic release of cadmium since industrialization has …
rare in the Earth’s crust, anthropogenic release of cadmium since industrialization has …
[PDF][PDF] WNT activates the AAK1 kinase to promote clathrin-mediated endocytosis of LRP6 and establish a negative feedback loop
…, MV Gammons, JM Bennett, RM Counago… - Cell reports, 2019 - cell.com
β-Catenin-dependent WNT signal transduction governs development, tissue homeostasis,
and a vast array of human diseases. Signal propagation through a WNT-Frizzled/LRP …
and a vast array of human diseases. Signal propagation through a WNT-Frizzled/LRP …
Hinge binder scaffold hopping identifies potent calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) inhibitor chemotypes
…, AS Santiago, RM Counago… - Journal of medicinal …, 2021 - ACS Publications
CAMKK2 is a serine/threonine kinase and an activator of AMPK whose dysregulation is linked
with multiple diseases. Unfortunately, STO-609, the tool inhibitor commonly used to probe …
with multiple diseases. Unfortunately, STO-609, the tool inhibitor commonly used to probe …
SGC-AAK1-1: a chemical probe targeting AAK1 and BMP2K
Inhibitors based on a 3-acylaminoindazole scaffold were synthesized to yield potent dual
AAK1/BMP2K inhibitors. Optimization furnished a small molecule chemical probe (SGC-AAK1-1…
AAK1/BMP2K inhibitors. Optimization furnished a small molecule chemical probe (SGC-AAK1-1…
Imperfect coordination chemistry facilitates metal ion release in the Psa permease
The relative stability of divalent first-row transition metal ion complexes, as defined by the
Irving-Williams series, poses a fundamental chemical challenge for selectivity in bacterial metal …
Irving-Williams series, poses a fundamental chemical challenge for selectivity in bacterial metal …
[HTML][HTML] Evolution of the B3 DNA binding superfamily: new insights into REM family gene diversification
Background The B3 DNA binding domain includes five families: auxin response factor (ARF),
abscisic acid-insensitive3 (ABI3), high level expression of sugar inducible (HSI), related to …
abscisic acid-insensitive3 (ABI3), high level expression of sugar inducible (HSI), related to …
[HTML][HTML] In depth analysis of kinase cross screening data to identify CAMKK2 inhibitory scaffolds
The calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) activates CAMK1,
CAMK4, AMPK, and AKT, leading to numerous physiological responses. The deregulation of …
CAMK4, AMPK, and AKT, leading to numerous physiological responses. The deregulation of …
AdcA and AdcAII employ distinct zinc acquisition mechanisms and contribute additively to zinc homeostasis in Streptococcus pneumoniae
…, JR Morey, F Behr, RM Couñago… - Molecular …, 2014 - Wiley Online Library
S treptococcus pneumoniae is a globally significant human pathogen responsible for nearly
1 million deaths annually. Central to the ability of S . pneumoniae to colonize and mediate …
1 million deaths annually. Central to the ability of S . pneumoniae to colonize and mediate …
Development of the first covalent monopolar spindle kinase 1 (MPS1/TTK) Inhibitor
Monopolar spindle kinase 1 (MPS1/TTK) is a key element of the mitotic checkpoint and
clinically evaluated as a target in the treatment of aggressive tumors such as triple-negative …
clinically evaluated as a target in the treatment of aggressive tumors such as triple-negative …