Background Lung adenocarcinomas (LUADs) lead to the majority of deaths attributable to
lung cancer. We performed whole-exome sequencing (WES) and immune profiling analyses …

Many aspects of the evolutionary process of tumorigenesis that are fundamental to cancer
biology and targeted treatment have been challenging to reveal, such as the divergence times …

Background Lung squamous cell carcinoma (LUSC) accounts for 20–30% of non-small cell
lung cancers (NSCLCs). There are limited treatment strategies for LUSC in part due to our …

Recent studies have revealed the mutational signatures underlying the somatic evolution of
cancer, and the prevalences of associated somatic genetic variants. Here we estimate the …

A major goal of cancer biology is determination of the relative importance of the genetic
alterations that confer selective advantage to cancer cells. Tumor sequence surveys have …

Cancer progression is an evolutionary process. During this process, evolving cancer cell
populations encounter restrictive ecological niches within the body, such as the primary tumor, …

Purpose: Human papillomavirus (HPV)-negative head and neck squamous cell carcinomas
(HNSCC) commonly bear disruptive mutations in TP53, resulting in treatment resistance. In …

… SG and JT verified the analytical methods. JY supervised the findings of this work. All …
Copyright: © 2018 Chen, Bindra, Mo, Hayman, Husain, Contessa, Gaffney, Townsend and Yu. This …

Activating mutations in RAS genes are associated with approximately 20% of all human
cancers. New targeted therapies show preclinical promise in inhibiting the KRAS G12C variant. …

As a devastating Ebola outbreak in West Africa continues, non-pharmaceutical control
measures including contact tracing, quarantine, and case isolation are being implemented. In …