User profiles for S. H. Orkin
Stuart OrkinVerified email at dfci.harvard.edu Cited by 149616 |
[HTML][HTML] Hematopoiesis: an evolving paradigm for stem cell biology
Establishment and maintenance of the blood system relies on self-renewing hematopoietic
stem cells (HSCs) that normally reside in small numbers in the bone marrow niche of adult …
stem cells (HSCs) that normally reside in small numbers in the bone marrow niche of adult …
[HTML][HTML] GATA-binding transcription factors in hematopoietic cells
SH Orkin - Blood, 1992 - Elsevier
Differentiation of hematopoietic cells involves progressive restriction of developmental
potential as pluripotent hematopoietic stem cells give rise to multipoten-tial progenitors that …
potential as pluripotent hematopoietic stem cells give rise to multipoten-tial progenitors that …
Diversification of haematopoietic stem cells to specific lineages
SH Orkin - Nature Reviews Genetics, 2000 - nature.com
Diverse types of blood cell (lineages) are produced from rare haematopoietic stem cells that
reside in the bone marrow. This process, known as haematopoiesis, provides a valuable …
reside in the bone marrow. This process, known as haematopoiesis, provides a valuable …
Epigenetic memory in induced pluripotent stem cells
Somatic cell nuclear transfer and transcription-factor-based reprogramming revert adult
cells to an embryonic state, and yield pluripotent stem cells that can generate all tissues. …
cells to an embryonic state, and yield pluripotent stem cells that can generate all tissues. …
[HTML][HTML] A comparative encyclopedia of DNA elements in the mouse genome
The laboratory mouse shares the majority of its protein-coding genes with humans, making
it the premier model organism in biomedical research, yet the two mammals differ in …
it the premier model organism in biomedical research, yet the two mammals differ in …
An early haematopoietic defect in mice lacking the transcription factor GATA-2
Blood cell development relies on the expansion and maintenance of haematopoietic stem
and progenitor cells in the embryo. By gene targeting in mouse embryonic stem cells, we …
and progenitor cells in the embryo. By gene targeting in mouse embryonic stem cells, we …
Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping
CYTOGENETIC analysis has identified chromosome Ilpl3 as the smallest overlap region for
deletions found in individuals with WAGR syndrome, which includes Wilms tumour (a …
deletions found in individuals with WAGR syndrome, which includes Wilms tumour (a …
Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1
…, E Robertson, WH Klein, SF Tsai, V D'Agati, SH Orkin… - Nature, 1991 - nature.com
THE zinc-finger transcription factor GATA-1 (previously known as GF-1, NF-E1 or Eryf 1 (refs
1-5)) binds to GATA consensus elements in regulatory regions of theα- and β-globin gene …
1-5)) binds to GATA consensus elements in regulatory regions of theα- and β-globin gene …
[HTML][HTML] An extended transcriptional network for pluripotency of embryonic stem cells
Much attention has focused on a small set of transcription factors that maintain human or mouse
embryonic stem (ES) cells in a pluripotent state. To gain a more complete understanding …
embryonic stem (ES) cells in a pluripotent state. To gain a more complete understanding …
[PDF][PDF] Mapping the mouse cell atlas by microwell-seq
Single-cell RNA sequencing (scRNA-seq) technologies are poised to reshape the current
cell-type classification system. However, a transcriptome-based single-cell atlas has not been …
cell-type classification system. However, a transcriptome-based single-cell atlas has not been …