User profiles for T. J. McHugh

Thomas McHugh

RIKEN Center for Brain Science
Verified email at riken.jp
Cited by 9303

NMDA receptors, place cells and hippocampal spatial memory

K Nakazawa, TJ McHugh, MA Wilson… - Nature Reviews …, 2004 - nature.com
N-methyl-D-aspartate receptors (NMDARs) in the rodent hippocampus have been shown to
be essential for spatial learning and memory, and for the induction of long-term synaptic …

Updating hippocampal representations: CA2 joins the circuit

MW Jones, TJ McHugh - Trends in neurosciences, 2011 - cell.com
The hippocampus integrates the encoding, storage and recall of memories, binding the
spatio-temporal and sensory information that constitutes experience and keeping episodes in …

[PDF][PDF] An integrated index: engrams, place cells, and hippocampal memory

TD Goode, KZ Tanaka, A Sahay, TJ McHugh - Neuron, 2020 - cell.com
The hippocampus and its extended network contribute to encoding and recall of episodic
experiences. Drawing from recent anatomical, physiological, and behavioral studies, we …

Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network

TJ McHugh, MW Jones, JJ Quinn, N Balthasar… - Science, 2007 - science.org
Forming distinct representations of multiple contexts, places, and episodes is a crucial function
of the hippocampus. The dentate gyrus subregion has been suggested to fulfill this role. …

Near-infrared deep brain stimulation via upconversion nanoparticle–mediated optogenetics

…, I Tsutsui-Kimura, KF Tanaka, X Liu, TJ McHugh - Science, 2018 - science.org
Optogenetics has revolutionized the experimental interrogation of neural circuits and holds
promise for the treatment of neurological disorders. It is limited, however, because visible …

[HTML][HTML] Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion

…, KA Pelkey, S Renaudineau, DL Buhl, TJ McHugh… - Cell, 2012 - cell.com
Adult-born granule cells (GCs), a minor population of cells in the hippocampal dentate gyrus,
are highly active during the first few weeks after functional integration into the neuronal …

[HTML][HTML] Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice

TJ McHugh, KI Blum, JZ Tsien, S Tonegawa… - Cell, 1996 - cell.com
To investigate the role of synaptic plasticity in the place-specific firing of the hippocampus,
we have applied multiple electrode recording techniques to freely behaving mice with a CA1 …

Transgenic inhibition of synaptic transmission reveals role of CA3 output in hippocampal learning

T Nakashiba, JZ Young, TJ McHugh, DL Buhl… - Science, 2008 - science.org
The hippocampus is an area of the brain involved in learning and memory. It contains parallel
excitatory pathways referred to as the trisynaptic pathway (which carries information as …

Single-cell bioluminescence imaging of deep tissue in freely moving animals

…, M Kiyama, H Okano, S Kizaka-Kondoh, TJ McHugh… - Science, 2018 - science.org
Bioluminescence is a natural light source based on luciferase catalysis of its substrate
luciferin. We performed directed evolution on firefly luciferase using a red-shifted and highly …

[PDF][PDF] Hippocampal CA3 output is crucial for ripple-associated reactivation and consolidation of memory

T Nakashiba, DL Buhl, TJ McHugh, S Tonegawa - Neuron, 2009 - cell.com
A widely held memory consolidation theory posits that memory of events and space is
initially stored in the hippocampus (HPC) in a time-limited manner and is consolidated in the …