User profiles for T. J. McHugh
Thomas McHughRIKEN Center for Brain Science Verified email at riken.jp Cited by 9303 |
NMDA receptors, place cells and hippocampal spatial memory
N-methyl-D-aspartate receptors (NMDARs) in the rodent hippocampus have been shown to
be essential for spatial learning and memory, and for the induction of long-term synaptic …
be essential for spatial learning and memory, and for the induction of long-term synaptic …
Updating hippocampal representations: CA2 joins the circuit
The hippocampus integrates the encoding, storage and recall of memories, binding the
spatio-temporal and sensory information that constitutes experience and keeping episodes in …
spatio-temporal and sensory information that constitutes experience and keeping episodes in …
[PDF][PDF] An integrated index: engrams, place cells, and hippocampal memory
The hippocampus and its extended network contribute to encoding and recall of episodic
experiences. Drawing from recent anatomical, physiological, and behavioral studies, we …
experiences. Drawing from recent anatomical, physiological, and behavioral studies, we …
Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network
Forming distinct representations of multiple contexts, places, and episodes is a crucial function
of the hippocampus. The dentate gyrus subregion has been suggested to fulfill this role. …
of the hippocampus. The dentate gyrus subregion has been suggested to fulfill this role. …
Near-infrared deep brain stimulation via upconversion nanoparticle–mediated optogenetics
Optogenetics has revolutionized the experimental interrogation of neural circuits and holds
promise for the treatment of neurological disorders. It is limited, however, because visible …
promise for the treatment of neurological disorders. It is limited, however, because visible …
[HTML][HTML] Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion
Adult-born granule cells (GCs), a minor population of cells in the hippocampal dentate gyrus,
are highly active during the first few weeks after functional integration into the neuronal …
are highly active during the first few weeks after functional integration into the neuronal …
[HTML][HTML] Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice
To investigate the role of synaptic plasticity in the place-specific firing of the hippocampus,
we have applied multiple electrode recording techniques to freely behaving mice with a CA1 …
we have applied multiple electrode recording techniques to freely behaving mice with a CA1 …
Transgenic inhibition of synaptic transmission reveals role of CA3 output in hippocampal learning
The hippocampus is an area of the brain involved in learning and memory. It contains parallel
excitatory pathways referred to as the trisynaptic pathway (which carries information as …
excitatory pathways referred to as the trisynaptic pathway (which carries information as …
Single-cell bioluminescence imaging of deep tissue in freely moving animals
Bioluminescence is a natural light source based on luciferase catalysis of its substrate
luciferin. We performed directed evolution on firefly luciferase using a red-shifted and highly …
luciferin. We performed directed evolution on firefly luciferase using a red-shifted and highly …
[PDF][PDF] Hippocampal CA3 output is crucial for ripple-associated reactivation and consolidation of memory
A widely held memory consolidation theory posits that memory of events and space is
initially stored in the hippocampus (HPC) in a time-limited manner and is consolidated in the …
initially stored in the hippocampus (HPC) in a time-limited manner and is consolidated in the …