User profiles for V. Weake
 | Vikki WeakeAssociate Professor of Biochemistry, Purdue University Verified email at purdue.edu Cited by 2410 |
[PDF][PDF] Histone ubiquitination: triggering gene activity
VM Weake, JL Workman - Molecular cell, 2008 - cell.com
Recently, many of the enzymes responsible for the addition and removal of ubiquitin from the
histones H2A and H2B have been identified and characterized. From these studies, it has …
histones H2A and H2B have been identified and characterized. From these studies, it has …
Inducible gene expression: diverse regulatory mechanisms
VM Weake, JL Workman - Nature Reviews Genetics, 2010 - nature.com
The rapid activation of gene expression in response to stimuli occurs largely through the
regulation of RNA polymerase II-dependent transcription. In this Review, we discuss events that …
regulation of RNA polymerase II-dependent transcription. In this Review, we discuss events that …
Transcriptional signatures of aging
R Stegeman, VM Weake - Journal of molecular biology, 2017 - Elsevier
Genome-wide studies of aging have identified subsets of genes that show age-related changes
in expression. Although the types of genes that are age regulated vary among different …
in expression. Although the types of genes that are age regulated vary among different …
SAGA‐mediated H2B deubiquitination controls the development of neuronal connectivity in the Drosophila visual system
Nonstop, which has previously been shown to have homology to ubiquitin proteases, is
required for proper termination of axons R1–R6 in the optic lobe of the developing Drosophila …
required for proper termination of axons R1–R6 in the optic lobe of the developing Drosophila …
[HTML][HTML] Transcriptome profiling of aging Drosophila photoreceptors reveals gene expression trends that correlate with visual senescence
Background Aging is associated with functional decline of neurons and increased incidence
of both neurodegenerative and ocular disease. Photoreceptor neurons in Drosophila …
of both neurodegenerative and ocular disease. Photoreceptor neurons in Drosophila …
SAGA function in tissue-specific gene expression
VM Weake, JL Workman - Trends in cell biology, 2012 - cell.com
The Spt-Ada-Gcn5-acetyltransferase (SAGA) transcription coactivator plays multiple roles in
regulating transcription because of the presence of functionally independent modules of …
regulating transcription because of the presence of functionally independent modules of …
Loss of Drosophila Ataxin-7, a SAGA subunit, reduces H2B ubiquitination and leads to neural and retinal degeneration
The Spt–Ada–Gcn5–acetyltransferase (SAGA) chromatin-modifying complex possesses
acetyltransferase and deubiquitinase activities. Within this modular complex, Ataxin-7 anchors …
acetyltransferase and deubiquitinase activities. Within this modular complex, Ataxin-7 anchors …
Post-transcription initiation function of the ubiquitous SAGA complex in tissue-specific gene activation
VM Weake, JO Dyer, C Seidel, A Box… - Genes & …, 2011 - genesdev.cshlp.org
The Spt–Ada–Gcn5–acetyltransferase (SAGA) complex was discovered from Saccharomyces
cerevisiae and has been well characterized as an important transcriptional coactivator that …
cerevisiae and has been well characterized as an important transcriptional coactivator that …
Proper splicing contributes to visual function in the aging Drosophila eye
Abstract Changes in splicing patterns are a characteristic of the aging transcriptome;
however, it is unclear whether these age‐related changes in splicing facilitate the progressive …
however, it is unclear whether these age‐related changes in splicing facilitate the progressive …
Optimising parameters of fused filament fabrication process to achieve optimum tensile strength using artificial neural network
Currently, the Additive Manufacturing (AM) process has become the most researched area,
leading to a revolution in the manufacturing industries. Among all additive manufacturing …
leading to a revolution in the manufacturing industries. Among all additive manufacturing …