Creation of human tumour cells with defined genetic elements

WC Hahn, CM Counter, AS Lundberg… - Nature, 1999 - nature.com
… 18, WC Hahn and RA Weinberg, unpublished observations) pre-senescent primary
human cells to multiply indefinitely. Moreover, ectopic hTERT enzyme expression enables …

Modelling the molecular circuitry of cancer

WC Hahn, RA Weinberg - Nature Reviews Cancer, 2002 - nature.com
Cancer arises from a stepwise accumulation of genetic changes that liberates neoplastic cells
from the homeostatic mechanisms that govern normal cell proliferation. In humans, at least …

[HTML][HTML] BET bromodomain inhibition as a therapeutic strategy to target c-Myc

…, IM Ghobrial, PG Richardson, RA Young, WC Hahn… - Cell, 2011 - cell.com
MYC contributes to the pathogenesis of a majority of human cancers, yet strategies to
modulate the function of the c-Myc oncoprotein do not exist. Toward this objective, we have …

[PDF][PDF] Defining a cancer dependency map

…, DE Root, TR Golub, JS Boehm, WC Hahn - Cell, 2017 - cell.com
Most human epithelial tumors harbor numerous alterations, making it difficult to predict which
genes are required for tumor survival. To systematically identify cancer dependencies, we …

Malignant astrocytic glioma: genetics, biology, and paths to treatment

…, JM Stommel, A Stegh, WC Hahn… - Genes & …, 2007 - genesdev.cshlp.org
Malignant astrocytic gliomas such as glioblastoma are the most common and lethal
intracranial tumors. These cancers exhibit a relentless malignant progression characterized by …

Next-generation characterization of the cancer cell line encyclopedia

…, MP Morrissey, F Stegmeier, R Schlegel, WC Hahn… - Nature, 2019 - nature.com
Large panels of comprehensively characterized human cancer models, including the Cancer
Cell Line Encyclopedia (CCLE), have provided a rigorous framework with which to study …

[HTML][HTML] A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen

…, SA Stewart, BR Stockwell, N Hacohen, WC Hahn… - Cell, 2006 - cell.com
To enable arrayed or pooled loss-of-function screens in a wide range of mammalian cell
types, including primary and nondividing cells, we are developing lentiviral short hairpin RNA (…

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

…, JP Mesirov, DE Root, DG Gilliland, T Jacks, WC Hahn - Nature, 2009 - nature.com
… Wei and members of the Hahn laboratory for discussions. High-throughput RNAi
screening was conducted at the RNAi Platform of the Broad Institute of MIT and Harvard. …

Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9

…, Y Wang, J Faber, JE Levine, J Wang, WC Hahn… - Nature, 2006 - nature.com
Leukaemias and other cancers possess a rare population of cells capable of the limitless
self-renewal necessary for cancer initiation and maintenance 1 , 2 , 3 , 4 , 5 , 6 , 7 . Eradication …

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

…, WR Sellers, R Schlegel, JA Wargo, WC Hahn… - Nature, 2010 - nature.com
Oncogenic mutations in the serine/threonine kinase B-RAF (also known as BRAF) are found
in 50–70% of malignant melanomas 1 . Pre-clinical studies have demonstrated that the B-…