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- June 3, 2017.
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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
Author Information
- Ditte Demontis1,2,3†,
- Raymond K. Walters4,5†,
- Joanna Martin5,6,7,
- Manuel Mattheisen1,2,3,8,9,
- Thomas D. Als1,2,3,
- Esben Agerbo1,10,11,
- Rich Belliveau5,
- Jonas Bybjerg-Grauholm1,12,
- Marie Bækvad-Hansen1,12,
- Felecia Cerrato5,
- Kimberly Chambert5,
- Claire Churchhouse4,5,13,
- Ashley Dumont5,
- Nicholas Eriksson14,
- Michael Gandal15,16,17,18,
- Jacqueline Goldstein4,5,13,
- Jakob Grove1,2,3,19,
- Christine S. Hansen1,12,20,
- Mads E. Hauberg1,2,3,
- Mads V. Hollegaard1,12,
- Daniel P. Howrigan4,5,
- Hailiang Huang4,5,
- Julian Maller5,21,
- Alicia R. Martin4,5,13,
- Jennifer Moran5,
- Jonatan Pallesen1,2,3,
- Duncan S. Palmer4,5,
- Carsten B. Pedersen1,10,11,
- Marianne G. Pedersen1,10,11,
- Timothy Poterba4,5,13,
- Jesper B. Poulsen1,12,
- Stephan Ripke4,5,13,22,
- Elise B. Robinson4,23,
- Kyle F. Satterstrom4,5,13,
- Christine Stevens5,
- Patrick Turley4,5,
- Hyejung Won15,16,
- ADHD Working Group of the Psychiatric Genomics Consortium (PGC), Early Lifecourse & Genetic Epidemiology (EAGLE) Consortium, 23andMe Research Team,
- Ole A. Andreassen24,
- Christie Burton25,
- Dorret Boomsma26,27,
- Bru Cormand28,29,30,31,
- Søren Dalsgaard10,
- Barbara Franke32,
- Joel Gelernter33,34,
- Daniel Geschwind15,16,17,
- Hakon Hakonarson35,
- Jan Haavik24,
- Henry Kranzler36,37,
- Jonna Kuntsi38,
- Kate Langley7,
- Klaus-Peter Lesch39,40,
- Christel Middeldorp26,41,42,
- Andreas Reif43,
- Luis A. Rohde44,45,
- Panos Roussos46,47,48,49,
- Russell Schachar25,
- Pamela Sklar46,47,48,
- Edmund Sonuga-Barke50,51,52,
- Patrick F. Sullivan53,54,
- Anita Thapar7,
- Joyce Tung14,
- Irwin Waldman31,
- Merete Nordentoft1,55,
- David M. Hougaard1,12,
- Thomas Werge1,20,56,
- Ole Mors1,57,
- Preben B. Mortensen1,2,10,11,
- Mark J. Daly4,5,13,
- Stephen V. Faraone58*,
- Anders D. Børglum1,2,3* and
- Benjamin M. Neale4,5,13*
- 1The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark
- 2Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark
- 3Department of Biomedicine – Human Genetics, Aarhus University, Aarhus, Denmark
- 4Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
- 5Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
- 6Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
- 7MRC Centre for Neuropsychiatric Genetics & Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom
- 8Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
- 9Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden
- 10National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark
- 11Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark
- 12Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark
- 13Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
- 1423andMe, Mountain View, California, United States of America
- 15Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
- 16Center for Autism Research and Treatment and Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California, USA
- 17Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
- 18Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California, USA
- 19Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark
- 20Institute of Biological Psychiatry, MHC Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark
- 21Genomics plc, Oxford, United Kingdom
- 22Department of Psychiatry, Charite Universitatsmedizin Berlin Campus Benjamin Franklin, Berlin, Germany
- 23Department of Epidemiology, Harvard Chan School of Public Health, Boston, Massachusetts, USA
- 24KG Jebsen Centre for Psychosis Research, Norway Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
- 25Psychiatry, Neurosciences and Mental Health, The Hospital for Sick Children, University of Toronto, Toronto, Canada
- 26Department of Biological Psychology, Neuroscience Campus Amsterdam, VU University, Amsterdam, The Netherlands
- 27EMGO Institute for Health and Care Research, Amsterdam, The Netherlands
- 28Microbiologia i Estadística, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
- 29Biomedical Network Research Centre on Rare Diseases (CIBERER), Barcelona, Spain
- 30Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain
- 31Institut de Recerca Pediàtrica Hospital Sant Joan de Déu, Barcelona, Catalonia, Spain
- 32Departments of Human Genetics (855) and Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands
- 33Department of Psychiatry, Genetics, and Neuroscience, Yale University School of Medicine, New Haven, Connecticut, USA
- 34Veterans Affairs Connecticut Healthcare Center, West Haven, Connecticut, USA
- 35The Center for Applied Genomics, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA
- 36Department of Psychiatry, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
- 37Veterans Integrated Service Network (VISN4) Mental Illness Research, Education, and Clinical Center (MIRECC), Crescenz VA Medical Center, Philadephia, PA, USA
- 38MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
- 39Division of Molecular Psychiatry, ADHD Clinical Research Unit, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Germany
- 40Department of Neuroscience, School for Mental Health and Neuroscience (MHENS), Maastricht University, The Netherlands
- 41Child Health Research Centre, University of Queensland, Brisbane Australia
- 42Child and Youth Mental Health Service, Children’s Health Queensland Hospital and Health Service, Brisbane, Australia
- 43Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Frankfurt, Germany
- 44Department of Psychiatry, Faculty of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
- 45ADHD Outpatient Clinic, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
- 46Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA
- 47Institute for Genomics and Multiscale Biology, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA
- 48Friedman Brain Institute, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA
- 49Mental Illness Research Education and Clinical Center (MIRECC), James J. Peters VA Medical Center, Bronx, New York, USA
- 50School of Psychology, University of Southampton, Southampton, United Kingdom
- 51Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium
- 52Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, United Kingdom
- 53Departments of Genetics and Psychiatry, University of North Carolina, Chapel Hill, NC, USA
- 54Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
- 55Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, University of Copenhagen, Copenhagen, Denmark
- 56Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
- 57Psychosis Research Unit, Aarhus University Hospital, Risskov, Denmark
- 58Departments of Psychiatry and Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, New York, USA
- Correspond with: Benjamin M. Neale (bneale{at}broadinstitute.org), Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. Anders D. Børglum (anders{at}biomed.au.dk) Department of Biomedicine – Human Genetics, Aarhus University, Aarhus, Denmark. Stephen V. Faraone (sfaraone{at}childpsychresearch.org)Departments of Psychiatry and Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, New York, USA.
↵† Equal contributions.